Results 31 to 40 of about 21,307 (263)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cyclic soil-structure interaction of integral railway bridges

Frontiers in Built Environment
Integral bridges with larger spans experience increased cyclic interaction with their backfill, particularly due to seasonal temperature changes. This can result in a continuous increase of earth pressure (during the summer positions) as well as an ...
Alexander Stastny, Alexander Stastny, Anas Emera, Vahid Galavi, Franz Tschuchnigg   +4 more
doaj   +1 more source

Identification of modal parameters of long-span bridges under various wind velocities

Advances in Bridge Engineering, 2022
The modal parameters identification of bridges under non-stationary environmental excitation has caught the attention of researchers. This paper studies the non-stationarity of wind velocity, and extracts the time-varying mean wind velocity based on a ...
Siying Lu, Lei Yan, Xuhui He, Hui Guo
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cracking of the End Diaphragm of a Post-tensioned Beam Bridge

Nordic Concrete Research, 2019
In concrete beam bridges, the end diaphragm at the end of the bridge is a common structural component that connects the main beams and transfers the beam loads to the bridge bearings.
Kuusela Mikko, Asp Olli, Laaksonen Anssi
doaj   +1 more source

Fracture toughness of old bridge steel

Budownictwo i Architektura, 2013
The subject of paper is related to problems the of fracture toughness of old steel bridge which was taken from the railway bridge, that was loaded during more than 100 years.
Eliza Mytych-Kumańska, Paweł Kossakowski   +1 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Influence of technology temperature on the fatigue cracking resistance of asphalt mixtures used for bridge pavement

Budownictwo i Architektura, 2014
Bridges are an integral part of road infrastructure. In times of the roadnetwork expansion in Poland a lot of bridges were constructed. Due to the nature of work, a bridge structure should comply with specific features and requirements.
Piotr Radziszewski, Andrzej Plewa, Karol Kowalski, Jan Król, Michał Sarnowski, Piotr Pokorski   +5 more
doaj   +1 more source

Effects of Geogrid Reinforcement on the Backfill of Integral Bridge Abutments

Buildings, 2023
The construction of integral bridges is one of the most effective methods to reduce bridges’ construction and in-service costs. However, there are associated geotechnical problems with their abutments backfill due to the integrated abutments.
Visar Farhangi, Mehdi Zadehmohamad, Armaghan Monshizadegan, MohammadAli Izadifar, Mohammad Javad Moradi, Hamed Dabiri   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source