Results 61 to 70 of about 402 (214)

Top-forms of leading singularities in nonplanar multi-loop amplitudes

European Physical Journal C: Particles and Fields, 2018
The on-shell diagram is a very important tool in studying scattering amplitudes. In this paper we discuss the on-shell diagrams without external BCFW bridges. We introduce an extra step of adding an auxiliary external momentum line. Then we can decompose
Baoyi Chen, Gang Chen, Yeuk-Kwan E. Cheung, Ruofei Xie, Yuan Xin   +4 more
doaj   +1 more source

Investigation on Flooding-Resistant Performance of Integral Abutment and Jointless Bridge

Advances in Civil Engineering, 2020
Bridge washouts connected to flood events are deemed one of the main reasons for structural collapse. Compared to traditional continuous jointed bridges, integral abutment and jointless bridges (IAJBs) have better lateral stability because there are no ...
Yizhou Zhuang, Keyao Wu, Liang Xu, Huihui Li, Diego Maria Barbieri, Zhumei Fu   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Study of concrete strength by non-destructive and destructive methods

Дороги і мости
Introduction. As a result of the military aggression of the Russian Federation against Ukraine, there is an urgent need to restore damaged and destroyed structures.
Bohdan Zelenskyi, Maksym Borysenko, Olena Ivonenko, Serhii Zavhorodniy   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Dynamic Fracture Criteria Evaluation of Bridge Structural Steel

The Baltic Journal of Road and Bridge Engineering, 2011
J-integral is the main effective and commonly used tool for elastic-plastic cracked material resistance assessment. Considering ductile behavior of bridges steel integral approach is suitable for fracture toughness evaluation.
Antanas Žiliukas, Marius Gintalas
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Effect of Connection Ductility on Composite Steel–Concrete Bridges

Applied Sciences
Connection behavior significantly influences the design efficiency of steel–concrete composite bridges. This study investigates the impact of shear connectors, specifically headed stud connectors, on the structural response of symmetric and skewed ...
Mohammad Mahdi Mohammadi Dehnavi, Alessandra De Angelis, Maria Rosaria Pecce   +2 more
doaj   +1 more source