Results 51 to 60 of about 131,926 (308)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Fractal-fractional estimations of Bullen-type inequalities with applications

open access: yesAin Shams Engineering Journal
The study of inequalities inside fractal domains has been stimulated by the growing interest in fractional calculus for the applied and mathematical sciences.
Saad Ihsan Butt   +3 more
doaj   +1 more source

On variational formulations of inner boundary value problems for infinite systems of elliptic equations of special kind [PDF]

open access: yesМатематичні Студії, 2012
We consider boundary value problems for infinite triangular systems of elliptic equations with variable coefficients in 3d Lipschitz domains. Variational formulations of Dirichlet, Neumann and Robin problems are received and their well posedness in ...
Yu. A. Muzychuk, R. S. Chapko
doaj  

Overdetermined problems in annular domains with a spherical-boundary component in space forms

open access: yesJournal of Inequalities and Applications, 2023
We obtain a Serrin-type symmetry of the solutions to various overdetermined boundary value problems in annular domains with a spherical-boundary component in space forms by using the maximum principle for suitable subharmonic functions and integral ...
Jihye Lee, Keomkyo Seo
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

The Jump Problem for Mixed-Type Equations with Defects on the Type Change Line

open access: yesBoundary Value Problems, 2010
The jump problem and problems with defects on the type change line for model mixed-type equations in the mixed domains are investigated. The explicit solutions of the jump problem are obtained by the method of integral equations and by the Fourier ...
Ahmed Maher
doaj   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Fixed Points for Pseudocontractive Mappings on Unbounded Domains

open access: yesFixed Point Theory and Applications, 2010
We give some fixed point results for pseudocontractive mappings on nonbounded domains which allow us to obtain generalizations of recent fixed point theorems of Penot, Isac, and Németh. An application to integral equations is given.
E. Llorens-Fuster   +1 more
doaj   +2 more sources

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