Results 91 to 100 of about 5,324,251 (245)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

The Integral Trees with Spectral Radius 3 [PDF]

open access: yes
There are eleven integral trees with largest eigenvalue 3.Integral graphs;graph spectra ...
Brouwer, A.E., Haemers, W.H.
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

STRATEGY OF VOCATIONAL GUIDANCE FOR THE SYSTEMATIZATION OF THE PROFESSIONAL MOTIVATION IN THE INTEGRAL FORMATION OF UNIVERSITY / ESTRATEGIA DE ORIENTACIÓN PROFESIONAL PARA LA SISTEMATIZACIÓN DE LA MOTIVACIÓN PROFESIONAL EN LA FORMACIÓN INTEGRAL DEL ESTUDIANTE UNIVERSITARIO

open access: yesDidasc@lia: didáctica y educación, 2012
This research has sought to respond to many of the conjectures raised on vocational guidance education university institutions. This study deals with a novel topical and issues of great importance to the process of integral formation of the College ...
Alma Rosa Rondón Martínez
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The Symmetric Sugeno Integral [PDF]

open access: yes
We propose an extension of the Sugeno integral for negative numbers, in the spirit of the symmetric extension of Choquet integral, also called \Sipos\ integral.
Michel Grabisch
core  

Betting for Integral Formation through the Models of Arts Education

open access: yesPensamiento Palabra y Obra, 2016
For a long time integral formation has been a main purpose of educational curricula. But even though it proves necessary on the ground of the benefits education may bring to human development, its outcomes are not always visible and many times it ...
Julia Margarita Barco Rodríguez
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Curriculum, human development and integral formation within the colombian caribbean

open access: yesPraxis, 2013
This article describes the reality of the colombian Caribbean from the perspective of human development integral to start to understand that problematic situations are opportunities to enhance the transformations that allow to retrieve the subject social
Álvaro Rodríguez Akle   +1 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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