Results 61 to 70 of about 4,454 (298)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On Bailey pairs for N $$ \mathcal{N} $$ = 2 supersymmetric gauge theories on S b 3 / ℤ r $$ {S}_b^3/{\mathbb{Z}}_r $$

Journal of High Energy Physics, 2023
We study Bailey pairs construction for hyperbolic hypergeometric integral identities acquired via the duality of lens partitions functions for the three-dimensional N $$ \mathcal{N} $$ = 2 supersymmetric gauge theories on S b 3 / ℤ r $$ {S}_b^3/{\mathbb ...
Ilmar Gahramanov, Batuhan Keskin, Dilara Kosva, Mustafa Mullahasanoglu   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Numerical continuation of canard orbits in slow-fast dynamical systems

, 2009
A trajectory of a system with two clearly separated time scales generally consists of fast segments (or jumps) followed by slow segments where the trajectory follows an attracting part of a slow manifold. The switch back to fast dynamics typically occurs
Desroches, MF, Osinga, HM, Krauskopf, B
core   +1 more source

DOUBLY WARPED PRODUCTS IN S-SPACE FORMS [PDF]

Romanian Journal of Mathematics and Computer Science, 2014
Recently, the author established a general inequality for doubly warped products in arbitrary Riemannian manifolds [14]. In the present paper, we obtain a similar inequality for doubly warped products isometrically immersed in S-space forms.
Andreea Olteanu
doaj  

Local stable manifold of Langevin differential equations with two fractional derivatives

Advances in Difference Equations, 2017
In this paper, we investigate the existence of local center stable manifolds of Langevin differential equations with two Caputo fractional derivatives in the two-dimensional case.
JinRong Wang, Shan Peng, D O’Regan
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Attractivity with asymptotic phase of local center manifolds and an application to one-parameter bifurcation for integral equations with infinite delay

Electronic Journal of Qualitative Theory of Differential Equations
For autonomous $C^1$-smooth integral equations with infinite delay, exponential attractivity with asymptotic phase of the local center manifolds of the equilibrium $0$, together with a reduction principle, is proved by means of a dynamical systems ...
Hideaki Matsunaga, Kouichi Murakami, Yutaka Nagabuchi   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Martingales on manifolds and geometric Ito calculus [PDF]

This work studies properties of stochastic processes taking values in a differential manifold M with a linear connection Γ, or in a Riemannian manifold with a metric connection.
Darling, R. W. R.
core