Results 91 to 100 of about 659,470 (267)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Saigo Fractional q-Differentiation Operator Involving Generalized q-Mittag–Leffler Function
Journal of MathematicsThe purpose of this study is to obtain the images of the generalized q-analogue of Mittag–Leffler functions under the Saigo fractional q-differentiation operator, where its argument consists of a factor xζxq−μ+ξ−θ.
Mulugeta Dawud Ali, D. L. Suthar
doaj +1 more source
Diagonalization of Abel’s Integral Operator [PDF]
SIAM Journal on Applied Mathematics, 1994 The author provides an explicit diagonalization of Abel's integral operator \(A\), given by \((Af) (x) =\) \(\int^ \infty_ x (y^ 2 - x^ 2)^{-1/2} f(y)dy\). This diagonalization has also been applied to stellar wind tomography, and apparently provides a quick diagonalization of \(A\).
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Graph operations and neighbor-integrity [PDF]
Mathematica Bohemica, 2004 Summary: Let \(G\) be a graph. A vertex subversion strategy of \(G\), say \(S\), is a set of vertices in~ \(G\) whose closed neighborhood is removed from~ \(G\). The survival-subgraph is denoted by \(G/S\). The neighbor-integrity of~ \(G\), NI\((G)\), is defined to be NI\((G) = \min _{S \subseteq V (G)} \{| S| + c (G/S)\}\), where~ \(S\) is any vertex ...
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Starlikeness Properties of a New Integral Operator for Meromorphic Functions
Journal of Applied Mathematics, 2011 We define here an integral operator ℋ𝛾1,…,𝛾𝑛 for meromorphic functions in the punctured open unit disk. Several starlikeness conditions for the integral operator ℋ𝛾1,…,𝛾𝑛 are derived.
Aabed Mohammed, Maslina Darus
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source