Results 91 to 100 of about 529,664 (281)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Journal of Function Spaces, 2017 In this article, we give the boundedness conditions in terms of Zygmund-type integral inequalities for oscillatory integral operators and fractional oscillatory integral operators on the vanishing generalized weighted Morrey spaces.
Bilal Çekiç +1 more
doaj +1 more source
Convolution Integral Operators
Siberian Mathematical Journal, 2018 The author considers the space $L_2:=L_2(\mathbb{R}^N)$ consisting of the measurable and square-integrable functions on $\mathbb{R}^{N}$. As in the work by \textit{L. Hörmander} [Acta Math. 104, 93--140 (1960; Zbl 0093.11402)], the author considers the space $L_2^2$ being the set of all continuous linear operators in $L_2$ which commute with shifts ...
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Volterra-stieltjes integral operators
Mathematical and Computer Modelling, 2005 The authors show that, under suitable growth and monotonicity assumptions on the data, the Volterra-Stieltjes integral operator \[ Vx(t) =\int^t_0v\bigl(s,x(s) \bigr)\,ds\,g(t,s)\quad (0\leq t\leq 1) \] maps the space \(C[0,1]\) into the space \(BV[0,1]\) (resp. \(BV[0,1]\cap C[0,1])\) and is both continuous and compact.
Józef Banas, Donal O'Regan
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Integral representations for Padé-type operators
Journal of Applied Mathematics, 2002 The main purpose of this paper is to consider an explicit form of the Padé-type operators. To do so, we consider the representation of Padé-type approximants to the Fourier series of the harmonic functions in the open disk and of the L p-functions on the
Nicholas J. Daras
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