Results 71 to 80 of about 527,109 (283)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
A class of generalized integral operators
Electronic Journal of Differential Equations, 2009 In this paper, we introduce a class of generalized integral operators that includes Fourier integral operators. We establish some conditions on these operators such that they do not have bounded extension on $L^{2}(mathbb{R}^{n})$.
Samir Bekkara +2 more
doaj
Univalence of certain integral operators
International Journal of Mathematics and Mathematical Sciences, 2000 We study some integral operators and determine conditions for the univalence of these integral operators.
Virgil Pescar, Shigeyoshi Owa
doaj +1 more source
A New Family of Boundary-Domain Integral Equations for a Mixed Elliptic BVP with Variable Coefficient [PDF]
, 2015 A mixed boundary value problem for the stationary heat transfer partial differential equation with variable coefficient is reduced to some systems of direct segregated parametrix-based Boundary-Domain Integral Equations (BDIEs).
Mikhailov, SE, Portillo, CF
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
, 2012 In this paper we study the shape differentiability properties of a class of boundary integral operators and of potentials with weakly singular pseudo-homogeneous kernels acting between classical Sobolev spaces, with respect to smooth deformations of the ...
Costabel, Martin +1 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On a class of $h$-Fourier integral operators
, 2013 In this paper, we study the $L^{2}$-boundedness and $L^{2}$-compactness of a class of $h$-Fourier integral operators. These operators are bounded (respectively compact) if the weight of the amplitude is bounded (respectively tends to $0)$
Abderrahmane, Senoussaoui +1 more
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source