Results 51 to 60 of about 11,070 (191)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Stability Evaluation and Parametric Optimization of Coal‐Concrete Composite Bearing Systems Under Mine‐Water‐Induced Deterioration: Experiments and FEINN Analysis

Energy Science &Engineering, EarlyView.
Mine‐water immersion tests reveal pronounced coal weakening (vs. minor concrete degradation), identifying coal pillars as the stability‐limiting component in composite dams. A coupled FEINN framework quantifies extreme‐pressure stability and ranks multi‐parameter designs via a normalized multi‐indicator scheme, enabling optimized dam configuration for ...
He Wen, Hongchuan Dai, Guixin Zhang, Pengzhe Li, Tong Yang, Cang Gong, Renbo Gao   +6 more
wiley   +1 more source

Local Polynomial Regression and Filtering for a Versatile Mesh‐Free PDE Solver

International Journal for Numerical Methods in Fluids, EarlyView.
A high‐order, mesh‐free finite difference method for solving differential equations is presented. Both derivative approximation and scheme stabilisation is carried out by parametric or non‐parametric local polynomial regression, making the resulting numerical method accurate, simple and versatile. Numerous numerical benchmark tests are investigated for
Alberto M. Gambaruto
wiley   +1 more source

Fast Calculation for the Flow and Heat Transfer of Tempered Fractional Maxwell Viscoelastic Fluid

International Journal for Numerical Methods in Fluids, EarlyView.
This study develops a tempered fractional Maxwell model to simulate unsteady thermal flow in viscoelastic fluids, capturing key rheological behaviors. A fast SOE‐based algorithm is proposed to improve the computational efficiency of the numerical scheme. Results reveal how key parameters influence fluid motion and heat transfer, demonstrating the model'
Yi Liu, Mochen Jiang, Libo Feng
wiley   +1 more source

Mapping the Global Clinical Landscape of Pharmacological Therapies for Heart Failure With Preserved Ejection Fraction: An Analysis Based on ClinicalTrials.gov (2003–2025)

iMetaMed, EarlyView.
This study analyzed 236 heart failure with preserved ejection fraction (HFpEF) pharmacological trials registered on ClinicalTrials.gov from 2003 to 2025, revealing a post‐2016 surge (76.3%), U.S. dominance (58.5%), and prominence of SGLT2 inhibitors/novel therapies (each 13.1%).
Yucheng Hou, Jingwei Zhao, Yuqian Tang, Tan Liu, Zhiao Zhang, Ziheng Wang, Han Shen   +6 more
wiley   +1 more source

New Drain Spacing Formulas Using the Variational Iteration Method

Irrigation and Drainage, EarlyView.
ABSTRACT In this study, the drain spacing is computed using the variational iteration method (VIM) to the linearized Boussinesq equation. By applying at most two iterations of the VIM method under three different initial condition scenarios, three equations for drain spacing calculation were derived. These equations predict values of drain spacing that
George Kargas, Leonidas Mindrinos, Paraskevi Londra   +2 more
wiley   +1 more source

Coping Practices of Small‐ and Medium‐Sized Enterprises Facing Power Asymmetry in Digital Platform Business

Strategic Change, EarlyView.
ABSTRACT Digital platform (DP) enterprises have risen to the top of the global economy by inverting traditional business models. They earn money through matchmaking, transaction facilitation, and efficient orchestration of other stakeholders' resources.
Lukas R. G. Fitz, Jochen Scheeg
wiley   +1 more source

Effect of HBr on Explosion Limits of Stoichiometric Hydrogen‐oxygen Mixture

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT This work, based on numerical simulations, discusses the effect of HBr as an inhibitor on the explosion limit of stoichiometric hydrogen‐oxygen gas mixture in a closed spherical vessel. The numerical simulation solves the complete governing equations for mass, momentum, species and energy.
Chunkan Yu, Peter Glarborg
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Advances and Current Progress of Dopant Engineering on All‐Inorganic Halide Perovskites Toward High‐Performance Scintillating Materials

MetalMat, EarlyView.
This review provides the latest advancement on lead‐free all‐inorganic perovskites, covering fundamental aspects, emerging synthetic routes, and scintillation properties. We highlight the dopant engineering strategy to favor the formation and efficient radiative recombination of self‐trapped excitons and the future development direction for the next ...
Galfin Anderias Adu, Viona Maria Djojo, Livia Janice Widiapradja, Noor Nisa Fayyaza, Lina Jaya Diguna, Muhammad Danang Birowosuto, Arramel Arramel   +6 more
wiley   +1 more source