Results 51 to 60 of about 543 (203)
Adaptive Sliding‐Mode Control of a Perturbed Diffusion Process With Pointwise In‐Domain Actuation
International Journal of Robust and Nonlinear Control, EarlyView.ABSTRACT A sliding mode–based adaptive control law is proposed for a class of diffusion processes featuring a spatially‐varying uncertain diffusivity and equipped with several point‐wise actuators located at the two boundaries of the spatial domain as well as in its interior.
Paul Mayr +3 more
wiley +1 more source
Sustainable Development, EarlyView.ABSTRACT The FAO's “blue transformation” roadmap necessitates a fundamental shift towards precision aquaculture to meet global food security targets while minimizing environmental footprints. This review provides a comprehensive overview of how artificial intelligence (AI) and decision support systems (DSS) serve as pivotal enablers for the “better ...
Mustafa Öz, Enes Üstüner
wiley +1 more source
Small Methods, EarlyView.Graphical Abstract. High‐speed atomic force microscopy enables real‐time, label‐free visualization of antibody interactions with individual extracellular vesicles. By quantifying binding frequency and dwell time, this approach reveals functional PD‐L1 accessibility that cannot be inferred from protein abundance alone, uncovering nanoscale heterogeneity
Reon Imakawa +10 more
wiley +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Soil salinization and alkalization often suppress microbial functional activity, triggering negative feedback loops in microbial metabolism, degrading nutrients and agricultural productivity.
Yuqi Chen, Lingying Xu, Xu Zhao
wiley +1 more source
Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals
Integrative Zoology, EarlyView.This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong +5 more
wiley +1 more source
6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human
Andrology, EarlyView.ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel +12 more
wiley +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
New biosensors and transgenic mice for multiplex cGMP imaging
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters +6 more
wiley +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source