Results 71 to 80 of about 11,070 (191)
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
New biosensors and transgenic mice for multiplex cGMP imaging
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters +6 more
wiley +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Computing Skinning Weights via Convex Duality
Computer Graphics Forum, EarlyView.We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley +1 more source
SDFs from Unoriented Point Clouds using Neural Variational Heat Distances
Computer Graphics Forum, EarlyView.We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from unoriented point clouds. We first compute a small time step of heat flow (middle) and then use its gradient directions to solve for a neural SDF (right). Abstract We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from ...
Samuel Weidemaier +5 more
wiley +1 more source
Controllable Intrinsic Surface Pattern Generation Using Slime Mold Simulations
Computer Graphics Forum, EarlyView.Abstract Surface‐based pattern simulations have proven valuable for texture design and scientific visualization, but existing methods face several limitations. Most simulations either target a narrow range of pattern types (e.g. spots, branching) or support a broad range of patterns at the cost of time‐consuming parameter tuning.
Jeffrey Layton +2 more
wiley +1 more source
Mesh Processing Non‐Meshes via Neural Displacement Fields
Computer Graphics Forum, EarlyView.Abstract Mesh processing pipelines are mature, but adapting them to newer non‐mesh surface representations—which enable fast rendering with compact file size—requires costly meshing or transmitting bulky meshes, negating their core benefits for streaming applications.
Yuta Noma +4 more
wiley +1 more source
Interpolated Adaptive Linear Reduced Order Modeling for Deformation Dynamics
Computer Graphics Forum, EarlyView.Abstract Linear reduced‐order modeling (ROM) is widely used for efficient simulation of deformation dynamics, but its accuracy is often limited by the fixed linearization of the reduced mapping. We propose a new adaptive strategy for linear ROM that allows the reduced mapping to vary dynamically in response to the evolving deformation state ...
Y. Tao, M. Chiaramonte, P. Fernandez
wiley +1 more source