Results 51 to 60 of about 342,732 (264)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Trkalian fields: ray transforms and mini-twistors

, 2013
We study X-ray and Divergent beam transforms of Trkalian fields and their relation with Radon transform. We make use of four basic mathematical methods of tomography due to Grangeat, Smith, Tuy and Gelfand-Goncharov for an integral geometric view on them.
Bailey T. N., Baird P., Dunajski M., Erdelyi A., Folland G. B., Gelfand I. M., Gelfand I. M., Gelfand I. M., Gelfand I. M., Gonzalez F. B., Gradshteyn I. S., Grangeat P., Jeffrey A., K. Saygili, Kanwal R. P., Louis A. K., Lundquist S., Markoe A., Marsden J. E., Minkowski H., Murray M. K., Palamadov V. P., Pantilie R., Pantilie R., Penrose R., Penrose R., Radon J., Ramm A. G., Rubin B., Semyanistyi V. I., Semyanistyi V. I., Shaw W. T., Stratton J. A., Watson G. N.   +33 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Integral Transforms in Number Theory

Axioms
Integral transforms play a fundamental role in science and engineering. Above all, the Fourier transform is the most vital, which has some specifications—Laplace transform, Mellin transform, etc., with their inverse transforms. In this paper, we restrict
Guodong Liu, Takako Kuzumaki, Shigeru Kanemitsu   +2 more
doaj   +1 more source

Mellin transform of quartic products of shifted Airy functions

, 2015
The Mellin transform of quartic products of shifted Airy functions is evaluated in a closed form. Some particular cases expressed in terms of the logarithm function and complete elliptic integrals special values are presented.Comment: Submitted to ...
Abramochkin, E. G., Razueva, E. V.
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Certain integral transforms concerning the product of family of polynomials and generalized incomplete functions

Moroccan Journal of Pure and Applied Analysis, 2020
In this article, we have derived some integral transforms of the polynomial weighted incomplete H-functions and incomplete ̄H-functions. The obtained image formulas are of general nature and may, as special cases, give rise to integral transforms ...
Meena Sapna, Bhatter Sanjay, Jangid Kamlesh, Purohit Sunil Dutt   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source