Results 51 to 60 of about 3,608 (255)

An uncoupled thermoelasticity problem for a semi-infinite layer with regard to its proper weight

Fracture and Structural Integrity, 2019
The exact solution of the uncoupled thermoelasticity problem for a semi-infinite elastic layer with regard to its proper weight was constructed. The originality of the proposed paper is based on reducing Lame equations to two jointly and one separately ...
A. Fesenko, N. Vaysfeld
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

NATURAL TRANSFORM AND SPECIAL FUNCTIONS

Journal of New Theory, 2017
Abstaract−The branch of integral transform attract many researcher in this field and hence various types of integral transforms are introduced. Natural transform is one of the newly defined transform which has wide range of applications in science and ...
Anil Dhondiram Chindhe, Sakharam Kiwne
doaj  

Heun Functions and Some of Their Applications in Physics

Advances in High Energy Physics, 2018
Most of the theoretical physics known today is described by using a small number of differential equations. For linear systems, different forms of the hypergeometric or the confluent hypergeometric equations often suffice to describe the system studied ...
M. Hortaçsu
doaj   +1 more source

Operational Approach and Solutions of Hyperbolic Heat Conduction Equations

Axioms, 2016
We studied physical problems related to heat transport and the corresponding differential equations, which describe a wider range of physical processes. The operational method was employed to construct particular solutions for them.
Konstantin Zhukovsky
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

New Extended Three-Variable Mittag-Leffler Type Functions

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
This article presents a systematic investigation of a new class of Mittag-Leffler-type functions in three variables. These functions are a natural and significant extension of the classical Mittag-Leffler function, and are constructed to correspond ...
Hasanov, A., Yuldashova, H.A.
doaj   +1 more source

Mathematical modeling of hereditary elastically deformable body on the basis of structural models and fractional integrodifferentiation Riemann-Liouville apparatus

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016
The standard one-dimensional generalized model of a viscoelastic body and some of its special cases-Voigt, Maxwell, Kelvin and Zener models are considered. Based on the V. Volterra hypothesis of hereditary elastically deformable solid body and the method
Eugeniy N Ogorodnikov, Vladimir P Radchenko, Luiza G Ungarova   +2 more
doaj   +1 more source