Results 151 to 160 of about 8,166 (301)

Integrality Gaps for Strong Linear Programming and Semidefinite Programming Relaxations

, 2011
The inapproximability for NP-hard combinatorial optimization problems lies in the heart of theoretical computer science. A negative result can be either conditional, where the starting point is a complexity assumption, or unconditional, where the ...
Georgiou, Konstantinos
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Editorial: Neuropsychology of human growth

Frontiers in Psychology
J. V. Orón Semper, Samuel Asensio, Francisco Ceric, Manuel E. Cortés, Inmaculada Lizasoain   +4 more
doaj   +1 more source

Integration [PDF]

Interactions, 2016
Ron Wakkary, Erik Stolterman
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Integrality ratio for group steiner trees and directed steiner trees

, 2003
We present an Ω(log 2 k) lower bound on the integrality ratio of the flow-based relaxation for the Group Steiner Tree problem, where k denotes the number of groups; this holds even for input graphs that are Hierarchically Well-Separated Trees, introduced
Nan Wang, Robert Krauthgamer, Eran Halperin, Aravind Srinivasan, Guy Kortsarz   +4 more
core  

The effects of Reiki practice on breast cancer patients: a systematic review. [PDF]

Support Care Cancer
Turan Z, Tülüce D.
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Inhibition of IL-17 Alleviates Blood-Brain Barrier Disruption Following Diffuse Axonal Injury Accompanied by Hyperglycemia Through the NF-κB Pathway. [PDF]

Mediators Inflamm
Xing Z, Wei X, Zhang M, Huang T, Zhao Y, Song J.   +5 more
europepmc   +1 more source