Results 131 to 140 of about 8,166 (301)
, 2016 Objective: to understand how the coordinators of technical schools in the Unified Health System perceive the application of the integrality principle in the training process of nursing technicians.
Lazzari,Daniele Delacanal +2 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Proving integrality gaps without knowing the linear program
, 2006 Proving integrality gaps for linear relaxations of NP optimization problems is a difficult task and usually undertaken on a case-by-case basis. We initiate a more systematic approach.
Béla Bollobás +3 more
core
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Proving integrality gaps without knowing the linear program
, 2002 Proving integrality gaps for linear relaxations of NP optimization problems is a difficult task and usually undertaken on a case-by-case basis. We initiate a more systematic approach.
Arora, Sanjeev +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
A transformatory ethic of inclusion : rupturing 'disability' and 'inclusion' for integrality
, 1999 Inclusion, within the context of intellectual disability, is a topical notion which underpins contemporary human service practices and policies within Western\ud Judeo-Christian societies.
Clapton, Jayne Ruth
core