Results 231 to 240 of about 57,554 (268)
Some of the next articles are maybe not open access.
Impact of Integrase inhibitors and tenofovir alafenamide on weight gain in people with HIV
Current Opinion in HIV and AIDS, 2021Purpose of review Obesity is increasing in people with HIV (PWH). This review aims to summarise the recent evidence investigating the associations between the use of integrase inhibitors and tenofovir alafenamide (TAF) with weight gain and the mechanisms
J. Lake, J. Trevillyan
semanticscholar +1 more source
ACS Synthetic Biology, 2019
Phage-derived integrases can catalyze irreversible, site-specific integration of transgenic payloads into a chromosomal locus, resulting in mammalian cells that stably express transgenes or circuits of interest.
Barbara Jusiak +8 more
semanticscholar +1 more source
Phage-derived integrases can catalyze irreversible, site-specific integration of transgenic payloads into a chromosomal locus, resulting in mammalian cells that stably express transgenes or circuits of interest.
Barbara Jusiak +8 more
semanticscholar +1 more source
Organic Process Research & Development, 2019
Bictegravir and dolutegravir are two recently approved integrase inhibitors for the treatment of HIV. A third inhibitor, cabotegravir, is in Phase 3 development.
D. Hughes
semanticscholar +1 more source
Bictegravir and dolutegravir are two recently approved integrase inhibitors for the treatment of HIV. A third inhibitor, cabotegravir, is in Phase 3 development.
D. Hughes
semanticscholar +1 more source
1995
Abstract The linear DNA copy of the HIV genome made by reverse transcription must be integrated into a chromosome of the infected cell in order to be stably maintained and efficiently transcribed. DNA integration is therefore a necessary step in the viral replication cycle. HIV DNA is inserted into the host genome by a specialized DNA
R Craigie, A B Hickman, A Engelman
openaire +1 more source
Abstract The linear DNA copy of the HIV genome made by reverse transcription must be integrated into a chromosome of the infected cell in order to be stably maintained and efficiently transcribed. DNA integration is therefore a necessary step in the viral replication cycle. HIV DNA is inserted into the host genome by a specialized DNA
R Craigie, A B Hickman, A Engelman
openaire +1 more source
Expert Opinion on Therapeutic Targets, 2001
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
openaire +2 more sources
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
openaire +2 more sources