Results 51 to 60 of about 54,271 (286)
Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis
Viruses, 2020 The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the reverse-transcribed viral DNA into the host chromosome. This function of IN has been well studied, and the knowledge gained has informed the design of small ...
Jennifer L. Elliott, Sebla B. Kutluay
doaj +1 more source
Update on Adverse Effects of HIV Integrase Inhibitors
Current Treatment Options in Infectious Diseases, 2019 The goal of this paper is to provide an up-to-date review of adverse events related to the class of integrase strand transfer inhibitors (INSTIs), which became the class of choice in few years.
A. Kołakowska +3 more
semanticscholar +1 more source
The SSV1 viral integrase is not essential
Virology, 2007 Viral integration is a widely conserved characteristic in viruses in all domains of life; however, its necessity is not well understood in many cases. Integration using tyrosine recombinases is one of the most widespread and best characterized mechanisms of integration. We completely removed the tyrosine recombinase integrase from the hyperthermophilic
Adam J. Clore, Kenneth M. Stedman
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Role of HIV Subtype Diversity in the Development of Resistance to Antiviral Drugs
Viruses, 2010 Despite the fact that over 90% of HIV-1 infected people worldwide harbor non‑subtype B variants of HIV-1, knowledge of resistance mutations in non-B HIV-1 and their clinical relevance is limited.
Bluma G. Brenner, Mark A. Wainberg
doaj +1 more source
Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants
Retrovirology, 2018 Integrase strand transfer inhibitors (INSTIs) are the class of antiretroviral (ARV) drugs most recently approved by the FDA for the treatment of HIV-1 infections.
Steven J. Smith +3 more
semanticscholar +1 more source
Structural and Functional Insights into Foamy Viral Integrase
Viruses, 2013 Successful integration of retroviral DNA into the host chromosome is an essential step for viral replication. The process is mediated by virally encoded integrase (IN) and orchestrated by 3'-end processing and the strand transfer reaction.
Cha-Gyun Shin +2 more
doaj +1 more source
Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition
Journal of Biological Chemistry, 2019 Antiretroviral inhibitors that are used to manage HIV infection/AIDS predominantly target three enzymes required for virus replication: reverse transcriptase, protease, and integrase.
A. Engelman
semanticscholar +1 more source
Lambda Integrase: Armed for Recombination [PDF]
Current Biology, 2005 Bacteriophage lambda moves its viral genome into and out of the bacterial chromosome using site-specific recombination. Crystal structures of reaction intermediates in this recombination pathway provide exciting new snapshots of full length lambda integrase interacting with both core and regulatory DNA elements.
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HIV drug resistance against strand transfer integrase inhibitors
Retrovirology, 2017 Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA genome into the host cell’s chromatin.
Kaitlin Anstett +3 more
semanticscholar +1 more source
Tangle Solutions for a Family of DNA-Rearranging Proteins [PDF]
, 2004 We study two systems of tangle equations that arise when modeling the action of the Integrase family of proteins on DNA. These two systems--direct and inverted repeats--correspond to two different possibilities for the initial DNA sequence. We present one new class of solutions to the tangle equations.
arxiv +1 more source