Results 31 to 40 of about 49,053 (243)
Molecules, 2023 As an important antiviral target, HIV-1 integrase plays a key role in the viral life cycle, and five integrase strand transfer inhibitors (INSTIs) have been approved for the treatment of HIV-1 infections so far.
Yu-Chan Wang +8 more
doaj +1 more source
Genome expansion by a CRISPR trimmer-integrase
, 2023 Supplemental data including cryo-EM structure ...
Owen Tuck (15193568)
core +1 more source
Integrase-Controlled Excision of Metal-Resistance Genomic Islands in Acinetobacter baumannii.
, 2018 Genomic islands (GIs) are discrete gene clusters encoding for a variety of functions including antibiotic and heavy metal resistance, some of which are tightly associated to lineages of the core genome phylogenetic tree.
K Rajakumar (7780529) +6 more
core +2 more sources
Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk [PDF]
, 2012 We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis.
Sessa, W.C. +10 more
core +1 more source
, 2021 Integrase Gene I and Integrase Gene II in Clinical Isolates of Pseudomonas ...
noha Mostafa (11313991) +2 more
core +1 more source
Structural and Functional Insights into Foamy Viral Integrase
Viruses, 2013 Successful integration of retroviral DNA into the host chromosome is an essential step for viral replication. The process is mediated by virally encoded integrase (IN) and orchestrated by 3'-end processing and the strand transfer reaction.
Cha-Gyun Shin +2 more
doaj +1 more source
Weight gain and integrase inhibitors [PDF]
Current Opinion in Infectious Diseases, 2020 Purpose of review Weight gain and obesity among people living with HIV (PLWH) is a serious problem that occurs often after initiation of antiretroviral therapy but may be worse with integrase strand transfer inhibitors (INSTIs).
Allison Ross, Eckard, Grace A, McComsey
openaire +2 more sources
Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase
Pharmaceuticals, 2019 One of the major factors contributing to HIV-1 drug resistance is suboptimal adherence to combination antiretroviral therapy (cART). Currently, recommended cART for HIV-1 treatment is a three-drug combination, whereas the pre-exposure prophylaxis (PrEP ...
Kamal Singh +2 more
doaj +1 more source
Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review
Pathogens and Immunity, 2016 Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV.
Said A. Hassounah +2 more
doaj +1 more source
The first total synthesis of lamellarin α 20-sulfate, a selective inhibitor of HIV-1 integrase [PDF]
, 2006 The first total synthesis of lamellarin α 20-sulfate (1), a selective inhibitor of HIV-1 integrase, has been completed. The lamellarin α core in which 13-OH and 20-OH were differentially protected by isopropyl and benzyl groups, respectively, was ...
Iwao, Masatomo +3 more
core +1 more source