Results 21 to 30 of about 49,053 (243)
Frontiers in Microbiology, 2022 In the worldwide health threat posed by antibiotic-resistant bacterial pathogens, mobile genetic elements (MGEs) play a critical role in favoring the dissemination of resistance genes.
Gang Zhang +14 more
doaj +1 more source
Retroviral integrases and their cousins [PDF]
Current Opinion in Structural Biology, 1996 The recently determined structures of the catalytic domains of HIV integrase, avian sarcoma virus integrase and the Mu transposase are strikingly similar to each other and also exhibit significant similarity to several nucleases. All these enzymes of cut polynucleotides, leaving 3'OH and 5'PO4 groups. The integrase and transposase also possess a strand-
Rice, Phoebe +2 more
openaire +2 more sources
, 2021 Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have become part of the preferred antiretroviral therapy (ART) first-line regimen in most low- to middle-income countries. With the extensive use of dolutegravir in
Manasa, Justen +7 more
core +1 more source
Prophage Integrase Typing Is a Useful Indicator of Genomic Diversity in Salmonella enterica
Frontiers in Microbiology, 2017 Salmonella enterica is a bacterial species that is a major cause of illness in humans and food-producing animals. S. enterica exhibits considerable inter-serovar diversity, as evidenced by the large number of host adapted serovars that have been ...
Anna Colavecchio +11 more
doaj +1 more source
Frontiers in Microbiology, 2022 Salmonella enterica serovar Indiana (S. Indiana) has aroused widespread concern as an important zoonotic pathogen. The molecular mechanism of multidrug resistance (MDR) in S. Indiana is not known and should be assessed.
Xuefeng Wang +6 more
doaj +1 more source
New Applications for Phage Integrases [PDF]
Journal of Molecular Biology, 2014 Within the last 25 years, bacteriophage integrases have rapidly risen to prominence as genetic tools for a wide range of applications from basic cloning to genome engineering. Serine integrases such as that from ϕC31 and its relatives have found an especially wide range of applications within diverse micro-organisms right through to multi-cellular ...
Fogg, Paul C M +4 more
openaire +5 more sources
Scientific Reports, 2017 Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the possible reasons may be the protection of integrase from proteasomal degradation by Ku70 subunit. We demonstrated that recombinant HIV-1 integrase and Ku70 form a stable complex,
Andrey N. Anisenko +6 more
doaj +1 more source
Integrase-On-Demand: bioprospecting integrases for targeted genomic insertion of genetic cargo. [PDF]
Nucleic Acids ResABSTRACT Integrases recognize defined sites within DNA and facilitate homologous recombination-independent transfer of genetic fragments. These innate capabilities render integrases as powerful biotechnology tools that mediate efficient site-specific integration of large genetic cargos.
McClain HM +8 more
europepmc +3 more sources
Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition [PDF]
, 2015 This work was supported by a grant from the Biotechnology and Biological Sciences Research Council (REF: BB/M000400/1 to MFW).The adaptive prokaryotic immune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements.
Bolt, Edward +17 more
core +1 more source
, 2019 A series of 5,6,7,8-tetrahydro-1,6-naphthyridine derivatives targeting the allosteric lens-epithelium-derived-growth-factor-p75 (LEDGF/p75)-binding site on HIV-1 integrase, an attractive target for antiviral chemotherapy, was prepared and screened for ...
Timothy Connolly (1754563) +20 more
core +2 more sources