Results 11 to 20 of about 87,868 (274)

Clinical use of HIV integrase inhibitors: a systematic review and meta-analysis. [PDF]

PLoS ONE, 2013
BackgroundOptimal regimen choice of antiretroviral therapy is essential to achieve long-term clinical success. Integrase inhibitors have swiftly been adopted as part of current antiretroviral regimens. The purpose of this study was to review the evidence
Peter Messiaen, Annemarie M J Wensing, Axel Fun, Monique Nijhuis, Nele Brusselaers, Linos Vandekerckhove   +5 more
doaj   +16 more sources

Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases [PDF]

Biomolecules, 2021
Integrases of different retroviruses assemble as functional complexes with varying multimers of the protein. Retroviral integrases require a divalent metal cation to perform one-step transesterification catalysis.
Anthony J. Rabe, Yow Yong Tan, Ross C. Larue, Kristine E. Yoder   +3 more
doaj   +3 more sources

Real‐world use of second‐generation integrase strand transfer inhibitors ( INSTI ) as switch therapy in the prospective ANRS ‐ CO3 ‐ AquiVIH ‐ NA cohort

HIV Medicine, EarlyView.
Abstract Objectives To characterize real‐world treatment switching in France to bictegravir (BIC or B) or dolutegravir (DTG)‐based regimens with a focus on treatment persistence, effectiveness (HIV‐1 RNA ≤50 copies/ml) and particular attention to the prevalence and incidence of comorbidities. Methods People living with HIV from the prospective ANRS‐CO3‐
O. Leleux, A. Peyrouny‐Mazeau, A. Perrier, M. Hessamfar, Gwenae Le Moal, D. Neau, L. Alleman, C. Cazanave, E. Lazaro, P. Duffau, A. Riché, Y Gérard, G. Barrière, Sandrine Reigadas, M.‐A. Vandenhende, F. Bonnet   +15 more
openalex   +2 more sources

Use of integrase-minus lentiviral vector for transient expression [PDF]

, 2012
Objective: Lentivirus-derived vectors are among the most promising viral vectors for gene therapy which is currently available, but their use in clinical practice is limited due to associated risk of insertional mutagenesis.
Azadeh, H., Farazmandfar, T., Haghshenas, M.R., Janbabai, G., Samaei, N.M., Shahreza, H.K.   +5 more
core   +4 more sources

Multimodal Functionalities of HIV-1 Integrase

Viruses, 2022
Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral cores, human immunodeficiency virus 1 (HIV-1) integrase has long ...
Alan N. Engelman, Mamuka Kvaratskhelia
doaj   +1 more source

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor. [PDF]

PLoS ONE, 2015
Understanding the HIV integrase protein and mechanisms of resistance to HIV integrase inhibitors is complicated by the lack of a full length HIV integrase crystal structure. Moreover, a lentiviral integrase structure with co-crystallised DNA has not been
Peter K Quashie, Ying-Shan Han, Said Hassounah, Thibault Mesplède, Mark A Wainberg   +4 more
doaj   +1 more source

S-SELeCT: a human-evolved serine integrase system for efficient large-cargo genome integration. [PDF]

Nucleic Acids Res
Farruggio AP, Jiang L, Duong K, Nguyen C, Kaddoura R, Tsai R.   +5 more
europepmc   +3 more sources

Novel Mobile Integrons and Strain-Specific Integrase Genes within Shewanella spp. Unveil Multiple Lateral Genetic Transfer Events within The Genus

Microorganisms, 2022
Shewanella spp. are Gram-negative bacteria that thrive in aquatic niches and also can cause infectious diseases as opportunistic pathogens. Chromosomal (CI) and mobile integrons (MI) were previously described in some Shewanella isolates.
Teolincacihuatl Ayala Nuñez, Gabriela N. Cerbino, María Florencia Rapisardi, Cecilia Quiroga, Daniela Centrón   +4 more
doaj   +1 more source

Imaging cell lineage with a synthetic digital recording system [PDF]

, 2020
Cell lineage plays a pivotal role in cell fate determination. Chow et al. demonstrate the use of an integrase-based synthetic barcode system called intMEMOIR, which uses the serine integrase Bxb1 to perform irreversible nucleotide edits.
Budde, Mark W., Cabrera, Maria, Cai, Long, Cho, Soomin, Chow, Ke-Huan K., Elowitz, Michael B., Frieda, Kirsten L., Granados, Alejandro A., Huang, Ting-hao, Koulena, Noushin, Lois, Carlos, Yoon, Shinae   +11 more
core   +1 more source

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis

Viruses, 2020
The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the reverse-transcribed viral DNA into the host chromosome. This function of IN has been well studied, and the knowledge gained has informed the design of small ...
Jennifer L. Elliott, Sebla B. Kutluay
doaj   +1 more source