Results 61 to 70 of about 54,271 (286)
Antimicrobial Agents and Chemotherapy, 2016 Bictegravir (BIC; GS-9883), a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase (IN), specifically targets IN strand transfer activity (50% inhibitory concentration [IC50] of 7.5 ± 0.3 nM) and HIV-1 integration in cells.
M. Tsiang +17 more
semanticscholar +1 more source
Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review
Pathogens and Immunity, 2016 Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV.
Said A. Hassounah +2 more
doaj +1 more source
Biochemical characterization of novel retroviral integrase proteins. [PDF]
PLoS ONE, 2013 Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication flanking the integrated ...
Allison Ballandras-Colas +4 more
doaj +1 more source
Bacterial transposases and retroviral integrases [PDF]
Molecular Microbiology, 1995 SummaryTransposable genetic elements have adopted two major strategies for their displacement from one site to another within and between genomes. One involves passage through an RNA intermediate prior to synthesis of a DNA copy while the other is limited uniquely to DNA intermediates.
Michael Chandler, Patrice Polard
openaire +3 more sources
Asian Journal of Organic Chemistry, EarlyView.The cascade Michael/intramolecular transamidation reactions of 3‐phenacylidene‐2‐indolinone derivatives bearing a trifluoromethyl group as a novel Michael acceptor with hydrazines yielded the corresponding pyrazolidin‐3‐one derivatives in good to high yields with excellent diastereoselectivity.
Ryo Tsuyusaki +4 more
wiley +1 more source
Interactions of Host Proteins with the Murine Leukemia Virus Integrase
Viruses, 2010 Retroviral infections cause a variety of cancers in animals and a number of diverse diseases in humans such as leukemia and acquired immune deficiency syndrome.
Barbara Studamire, Stephen P. Goff
doaj +1 more source
Frontiers in Medicine, 2022 Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus most prevalent in southwestern Japan, sub-Saharan Africa, Australia, South America, and the Caribbean. Latest figures approximate 10 million people worldwide to be infected with HTLV-1.
Bethany S. Schneiderman +2 more
doaj +1 more source
Clinical Pharmacokinetics, 2018 Prevention of mother-to-child transmission of HIV and optimal maternal treatment are the most important goals of antiretroviral therapy in pregnant women with HIV.
Ruben van der Galiën +6 more
semanticscholar +1 more source
Development of a novel in vitro assay for the evaluation of integron DNA integrase activity
Biotechnology & Biotechnological Equipment, 2016 Integrons play an important role in multidrug resistance. The integron platform codes for integrase (intI) that is required for gene cassette integration through site-specific recombination.
Fatemeh Tohidi +6 more
doaj +1 more source
Tolerability of integrase inhibitors in a real-life setting
Journal of Antimicrobial Chemotherapy, 2017 Background Integrase inhibitors have shown better tolerability than other drugs in clinical trials, but some post-marketing data have suggested potential differences among them.
J. Peñafiel +15 more
semanticscholar +1 more source