Results 131 to 140 of about 2,826,854 (328)

The association between HIV drug resistance testing, viral suppression and mortality in Ontario: a retrospective cohort study

HIV Medicine, EarlyView.
Abstract Background Drug resistance compromises the effectiveness of antiretroviral therapy (ART). Resistance testing prior to initiating therapy is recommended in guidelines in many high‐income countries, and it has been shown to improve outcomes after first‐line ART regimen failure. There is limited evidence on its role in treatment‐naïve individuals.
Lawrence Mbuagbaw, Carmen H. Logie, Lehana Thabane, Fiona Smaill, Marek Smieja, Ann N. Burchell, Beth Rachlis, Jean Eric Tarride, Abigail E. Kroch, Tony Mazzulli, Elizabeth Alvarez, Francis Nguyen, Richard Perez, Cristian Garcia, Jessyca Matos Silva, Hsien Seow   +15 more
wiley   +1 more source

Intrapatient Development of Multi-Class Drug Resistance in an Individual Infected with HIV-1 CRF01_AE

Infection and Drug Resistance, 2021
Xiaorong Peng,* Yufan Xu,* Ying Huang, Biao Zhu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China*These ...
Peng X, Xu Y, Huang Y, Zhu B
doaj  

Is Resistance to Dolutegravir Possible When This Drug Is Used in First-Line Therapy?

Viruses, 2014
Dolutegravir (DTG) is an HIV integrase inhibitor that was recently approved for therapy by the Food and Drug Administration in the United States. When used as part of first-line therapy, DTG is the only HIV drug that has not selected for resistance ...
Thibault Mesplède, Mark A. Wainberg
doaj   +1 more source

Characterization of HIV-1 Integrase Reactions with Viral DNA [PDF]

, 2013
HIV-1 integrase (integrase) catalyzes the insertion of viral DNA into human chromosomes and is a focus for development of anti-integrase inhibitors to combat HIV infection. Integrase catalyzes two steps, a DNA-end cleavage reaction (3’-processing), and a
Kettlewell, Joanna
core   +1 more source

Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome

PLoS ONE, 2017
T97A is an HIV-1 integrase polymorphism associated with integrase strand transfer inhibitor (INSTI) resistance. Using pooled data from 16 clinical studies, we investigated the prevalence of T97A (pre-existing and emergent) and its impact on INSTI ...
M. Abram, Renee R. Ram, N. Margot, Tiffany L. Barnes, K. White, C. Callebaut, Michael D. Miller   +6 more
semanticscholar   +1 more source

Cardiovascular risk knowledge stratified by predicted cardiovascular risk level among people living with HIV attending a tertiary HIV care centre in Gaborone, Botswana: A cross‐sectional study

HIV Medicine, EarlyView.
Abstract Objectives While people living with HIV are at an increased risk of cardiovascular disease (CVD), the level of awareness of CVD risk in this population is not well documented. This study aimed to assess the association between CVD risk factor knowledge and estimated CVD risk among people living with HIV.
Bernard Morapedi, Onkabetse Julia Molefe‐Baikai, Onkarabile Hiri, Kago Kebotsamang, Thato Moshomo, Mosepele Mosepele   +5 more
wiley   +1 more source

Clinical effectiveness of dolutegravir in the treatment of HIV/AIDS [PDF]

, 2015
Huda Taha,1 Archik Das,2 Satyajit Das1,3 1Integrated Sexual Health Service Coventry and Warwickshire Partnership NHS Trust, Coventry, 2School of Medicine, Birmingham University, Birmingham, 3Coventry University, Coventry, UK Abstract: Dolutegravir (DTG)
Das, A., Das, S., Taha, H.
core   +3 more sources

In vitro activity of dolutegravir against wild-type and integrase inhibitor-resistant HIV-2

Retrovirology, 2015
BackgroundDolutegravir recently became the third integrase strand transfer inhibitor (INSTI) approved for use in HIV-1–infected individuals. In contrast to the extensive dataset for HIV-1, in vitro studies and clinical reports of dolutegravir for HIV-2 ...
Robert A. Smith, Dana N. Raugi, C. Pan, P. Sow, M. Seydi, J. Mullins, G. Gottlieb   +6 more
semanticscholar   +1 more source

Leukocyte count and new‐onset diabetes mellitus in people with HIV: A longitudinal study

HIV Medicine, EarlyView.
Abstract Objectives The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte–DM association is limited. Methods We included participants of the Swiss HIV Cohort Study with new‐onset DM
Sophia C. Meyer, Zoe Klein, Isabella C. Schoepf, Christian W. Thorball, Marco Labarile, Neeltje A. Kootstra, Peter Reiss, Lene Ryom, Dominique L. Braun, Maria C. Thurnheer, Catia Marzolini, Christian R. Kahlert, Enos Bernasconi, Matthias Cavassini, Annalisa Marinosci, Jacques Fellay, Huldrych F. Günthard, Roger D. Kouyos, Bruno Ledergerber, Philip E. Tarr, the Swiss HIV Cohort Study, I Abela, K Aebi‐Popp, A Anagnostopoulos, M Battegay, E Bernasconi, DL Braun, HC Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, HF Günthard, A Hachfeld, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, M Huber, D Jackson‐Perry, patient representatives, CR Kahlert, O Keiser, T Klimkait, RD Kouyos, H Kovari, K Kusejko, N Labhardt, K Leuzinger, B Martinez de Tejada, C Marzolini, KJ Metzner, N Müller, J Nemeth, D Nicca, J Notter, P Paioni, G Pantaleo, M Perreau, A Rauch, L Salazar‐Vizcaya, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, G Wandeler, M Weisser, S. Yerly   +75 more
wiley   +1 more source

CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects

Journal of Translational Medicine, 2004
Background CD8+ T cell responses are known to be important to the control of HIV-1 infection. While responses to reverse transcriptase and most structural and accessory proteins have been extensively studied, CD8 T cell responses specifically directed to
Yu Xu G, Fitzpatrick Cecily A, Rathod Almas, Addo Marylyn M, Rodriguez William R, Perkins Beth, Rosenberg Eric S, Altfeld Marcus, Walker Bruce D   +8 more
doaj   +1 more source