Results 131 to 140 of about 38,544 (277)

Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. [PDF]

, 2019
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood ...
Anton, Peter A, Deming, Timothy, Elliott, Julie, Fulcher, Jennifer A, Ibarrondo, F Javier, Kickhoefer, Valerie A, Maynard, Heather D, Mrazek, Jan, Rome, Leonard H, Tamshen, Kyle, Wollenberg, Alexander L, Yang, Otto O   +11 more
core  

Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors [PDF]

, 2010
Kavya Ramkumar, V. N. Yarovenko, A. S. Nikitina, И. В. Заварзин, Mikhail M. Krayushkin, L. V. Kovalenko, Adrian Esqueda, Srinivas Odde, Nouri Neamati   +8 more
openalex   +1 more source

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase [PDF]

, 2019
Ping Gao, Xiqiang Cheng, Lin Sun, Shu Song, Mar Álvarez, Joanna Luczkowiak, Christophe Pannecouque, Erik De Clercq, Luis Menéndez‐Arias, Peng Zhan, Xinyong Liu   +10 more
openalex   +1 more source

Screening for Antiviral Inhibitors of the HIV Integrase–LEDGF/p75 Interaction Using the AlphaScreen™ Luminescent Proximity Assay [PDF]

, 2008
Yan Hou, Debra E McGuinness, Andrew Prongay, Boris Feld, Paul Ingravallo, Robert A. Ogert, Charles A. Lunn, John A. Howe   +7 more
openalex   +1 more source

From ligand to complexes: inhibition of HIV-1 Integrase by beta-diketo acid metal complexes [PDF]

, 2006
Recently, a class of compounds bearing a β-diketo acid moiety have emerged as the most promising lead in anti-HIV-1 IN drug discovery. It is believed that the β-diketo acid pharmacophoric motif could be involved in a functional sequestration of one or ...
Al-Mawsawi, Laith Q., Bacchi, Alessia, Carcelli, Mauro, Derudas, Marco, Fisicaro, Emilia, Gates, Paul, Neamati, Nouri, Rogolino, Dominga, Sechi, Mario   +8 more
core  

Molecular mechanism of HIV‐1 integrase–vDNA interactions and strand transfer inhibitor action: A molecular modeling perspective

, 2011
Weiwei Xue, Huanxiang Liu, Xiaojun Yao
openalex   +2 more sources

Tricyclic HIV integrase inhibitors: VI. SAR studies of ‘benzyl flipped’ C3-substituted pyrroloquinolines

, 2008
Sammy Metobo, Michael Mish, Haolun Jin, Salman Jabri, Rachael Lansdown, Xiaowu Chen, Manuel Tsiang, Matthew Wright, Choung U. Kim   +8 more
openalex   +1 more source

Repositioning HIV-1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties

, 2012
Li‐Fan Zeng, Yong Wang, Roza Kazemi, Shili Xu, Zhong-Liang Xu, Tino W. Sanchez, Liu-Meng Yang, Bikash Debnath, Srinivas Odde, Hua Xie, Yong‐Tang Zheng, Jian Ding, Nouri Neamati, Ya-Qiu Long   +13 more
openalex   +1 more source

7‐Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir [PDF]

, 2018
Robert Ziegler, Bimbisar Desai, Jo‐Ann Jee, B. Frank Gupton, Thomas D. Roper, Timothy F. Jamison   +5 more
openalex   +1 more source

Therapeutic Opportunities in Infectious Diseases: Highlights from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, London, UK [PDF]

, 2013
Alderton, W K, Anderson, Rosaleen, Collingwood, S P, Pryde, D C   +3 more
core   +1 more source