Results 61 to 70 of about 2,808,349 (298)

Dolutegravir-based regimen maintains virological success in a patient with archived mutations to integrase inhibitors [PDF]

, 2017
no abstract ...
Falasca, Francesca, Mazzuti, Laura, Mezzaroma, Ivano, Turriziani, Ombretta   +3 more
core   +1 more source

Weight Gain Associated with Integrase Stand Transfer Inhibitor Use in Women.

Clinical Infectious Diseases, 2019
BACKGROUND Integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is recommended for HIV management. Although studies have suggested associations between INSTIs and weight gain, women living with HIV (WLHIV) are underrepresented ...
A. Kerchberger, A. Sheth, Christine D. Angert, C. Mehta, N. Summers, I. Ofotokun, D. Gustafson, S. Weiser, Anjali Sharma, A. Adimora, A. French, M. Augenbraun, Jennifer Cocohoba, S. Kassaye, H. Bolivar, Usha Govindarajulu, D. Konkle-Parker, E. Golub, Cecile D. Lahiri   +18 more
semanticscholar   +1 more source

Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

PLoS Pathogens, 2017
The kinetics of HIV-1 decay under treatment depends on the class of antiretrovirals used. Mathematical models are useful to interpret the different profiles, providing quantitative information about the kinetics of virus replication and the cell ...
E. F. Cardozo, A. Andrade, J. Mellors, D. Kuritzkes, A. Perelson, R. Ribeiro, R. Ribeiro   +6 more
semanticscholar   +1 more source

Inhibitors of human immunodeficiency virus integrase. [PDF]

Proceedings of the National Academy of Sciences, 1993
In an effort to further extend the number of targets for development of antiretroviral agents, we have used an in vitro integrase assay to investigate a variety of chemicals, including topoisomerase inhibitors, antimalarial agents, DNA binders, naphthoquinones, the flavone quercetin, and caffeic acid phenethyl ester as potential human immunodeficiency ...
Kurt W. Kohn, Yves Pommier, Mark R. Fesen, François Leteurtre   +3 more
openaire   +3 more sources

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 ...
Daria J Hazuda
doaj   +1 more source

HIV-1 integrase resistance among antiretroviral treatment naive and experienced patients from Northwestern Poland

BMC Infectious Diseases, 2012
Background HIV integrase inhibitor use is limited by low genetic barrier to resistance and possible cross-resistance among representatives of this class of antiretrovirals.
Parczewski Miłosz, Bander Dorota, Urbańska Anna, Boroń-Kaczmarska Anna   +3 more
doaj   +1 more source

Undetectable proviral DNA and viral RNA levels after raltegravir administration in two cats with natural feline leukemia virus infection

Brazilian Journal of Veterinary Medicine, 2022
Feline leukemia virus (FeLV) infection was discovered over 50 years ago; however, the serious clinical changes associated with FeLV infection still have great importance in the diagnosis, prevention, and clinical management of symptomatic patients ...
Carla Regina Gomes Rodrigues Santos, Isabela Torres Ferreira, Renata Beranger, Julia Possebon Santi, Mariana Palha de Brito Jardim, Heloisa Justen Moreira de Souza   +5 more
doaj   +1 more source

Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.

Journal of Antimicrobial Chemotherapy, 2019
BACKGROUND Integrase strand transfer inhibitors (INSTIs) are expected to be widely adopted globally, requiring surveillance of resistance emergence and transmission.
P. Tzou, Soo-Yon Rhee, D. Descamps, Dana S. Clutter, B. Hare, O. Mor, M. Grudé, N. Parkin, Michael R Jordan, S. Bertagnolio, J. Schapiro, P. R. Harrigan, A. Geretti, A. Marcelin, Robert W Shafer   +14 more
semanticscholar   +1 more source

Different Pathways Leading to Integrase Inhibitors Resistance [PDF]

Frontiers in Microbiology, 2017
Integrase strand-transfer inhibitors (INSTIs), such as raltegravir (RAL), elvitegravir, or dolutegravir (DTG), are efficient antiretroviral agents used in HIV treatment in order to inhibit retroviral integration. By contrast to RAL treatments leading to well-identified mutation resistance pathways at the integrase level, recent clinical studies report ...
Eloïse Thierry, Olivier Delelis, Eric Deprez   +2 more
openaire   +3 more sources

The Evolution of Drug Resistance Interpretation Algorithms: ANRS, REGA and Extension of Resistance Analysis to HIV-1 Group O and HIV-2 [PDF]

, 2012
Antiretroviral drug resistance is mostly linked to a complex interaction of several amino acids with variable importance or a single amino acid. To facilitate the interpretation of observed mutation patterns, hospital university centers have developed ...
Eberle, Josef, Gürtler, Lutz
core   +1 more source