Results 61 to 70 of about 19,019 (189)

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase [PDF]

, 2000
Amy S. Espeseth, Peter J. Felock, Abigail Wolfe, Marc Witmer, Jay A. Grobler, Neville J. Anthony, Melissa S. Egbertson, Jeffrey Y. Melamed, Steve Young, Terence G. Hamill, James L. Cole, Daria J. Hazuda   +11 more
openalex   +1 more source

Maintenance of Viral Suppression after Optimization Therapy from Etravirine Plus Raltegravir to Rilpivirine Plus Dolutegravir in HIV-1-Infected Patients

Journal of the International Association of Providers of AIDS Care, 2019
Non-nucleoside reverse-transcriptase inhibitor plus integrase strand transfer inhibitor–based dual therapies are an attractive simplification, nucleoside reverse transcriptase inhibitor-sparing strategy for experienced human immunodeficiency virus ...
Niccolò Riccardi MD, Filippo Del Puente MD, Lucia Taramasso MD, Antonio Di Biagio MD   +3 more
doaj   +1 more source

A New Class of HIV-1 Integrase Inhibitors: The 3,3,3‘,3‘-Tetramethyl-1,1‘-spirobi(indan)-5,5‘,6,6‘-tetrol Family [PDF]

, 2000
Valentina Molteni, Denise Rhodes, Kathleen Rubins, Mark Hansen, Frederic D. Bushman, Jay S. Siegel   +5 more
openalex   +1 more source

Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV

Drug Design, Development and Therapy, 2015
Christopher E Kandel,1 Sharon L Walmsley1,21Department of Medicine, University of Toronto, Toronto, ON, Canada; 2Division of Infectious Diseases, University Health Network, Toronto, ON, CanadaAbstract: Dolutegravir is the newest integrase strand transfer
Kandel CE, Walmsley SL
doaj  

Intracellular Expression of Single-Chain Variable Fragments To Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase [PDF]

, 2001
P Levy-Mintz, Lingxun Duan, Huizhong Zhang, Baocheng Hu, Geethanjali Dornadula, Minghua Zhu, Joseph Kulkosky, Diane Bizub-Bender, Anna Marie Skalka, Roger J. Pomerantz   +9 more
openalex   +1 more source

Inhibition of Human Immunodeficiency Virus Type 1 Isolates by the Integrase Inhibitor L-731,988, a Diketo Acid [PDF]

, 2002
Ryan Reinke, Deborah J Lee, William E. Robinson   +2 more
openalex   +1 more source

Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis

Heliyon, 2018
Integrase (IN) plays an essential role in HIV-1 replication, by mediating integration of the viral genome into the host cell genome. IN is a potential target of antiretroviral (ARV) therapeutic drugs such as ALLINI, Raltegravir (RAL), and Elvitegravir ...
Hotma Martogi Lorensi Hutapea, Yustinus Maladan, Widodo   +2 more
doaj  

Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors

Viruses
Allosteric HIV-1 Integrase (IN) Inhibitors or ALLINIs bind at the dimer interface of the IN, away from the enzymatic catalytic site, and disable viral replication by inducing over-multimerization of IN.
Jian Sun, Jacques J. Kessl
doaj   +1 more source

Development of H51Y and E157Q mutations for integrase inhibitor resistance in a patient undergoing treatment for pulmonary tuberculosis: A case report. [PDF]

SAGE Open Med Case Rep, 2023
Farias LABG, Saboya MF, Ponte Fernandes N, Perdigão Neto LV, de Arruda EAG.   +4 more
europepmc   +1 more source

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques [PDF]

, 2004
Daria J. Hazuda, Steven D. Young, James P. Guare, Neville J. Anthony, Robert Gomez, John Wai, Joseph P. Vacca, Larry Handt, Sherri L. Motzel, Hilton J. Klein, Geethanjali Dornadula, Robert M. Danovich, Marc Witmer, Keith A. Wilson, Lynda Tussey, William A. Schleif, Lori S. Gabryelski, Lixia Jin, Michael D. Miller, Danilo R. Casimiro, Emilio A. Emini, John W. Shiver   +21 more
openalex   +1 more source