Results 61 to 70 of about 2,826,854 (328)

Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection [PDF]

, 2016
Indexación: Web of Science.During the early steps of infection, retroviruses must direct the movement of the viral genome into the nucleus to complete their replication cycle.
Arriagada, Gloria, Cancino, Jorge, Goff, Stephen P., Opazo, Tatiana, Valle-Tenney, Roger   +4 more
core   +1 more source

Impact of Integrase Inhibitors on Weight

Access Microbiology, 2020
Current evidence suggests that Integrase Strand Transfer Inhibitors (INSTI) are associated with excess weight gain. These increases are particularly significant for black people and women. Clinic notes of 84 patients stable on INSTI for at least 18 months and attending HIV outpatient clinics at Castle Hill Hospital, Hull Royal Infirmary,
Anda Samson, Lorraine Cullen, Hiten Thaker, Kate Adams, Sarah Harrison, Maithili Varadarajan   +5 more
openaire   +2 more sources

Inhibitors of human immunodeficiency virus integrase. [PDF]

Proceedings of the National Academy of Sciences, 1993
In an effort to further extend the number of targets for development of antiretroviral agents, we have used an in vitro integrase assay to investigate a variety of chemicals, including topoisomerase inhibitors, antimalarial agents, DNA binders, naphthoquinones, the flavone quercetin, and caffeic acid phenethyl ester as potential human immunodeficiency ...
Kurt W. Kohn, Yves Pommier, Mark R. Fesen, François Leteurtre   +3 more
openaire   +3 more sources

7‐Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

Angewandte Chemie, 2018
Dolutegravir (DTG), an important active pharmaceutical ingredient (API) used in combination therapy for the treatment of HIV, has been synthesized in continuous flow. By adapting the reported GlaxoSmithKline process chemistry batch route for Cabotegravir,
Robert E. Ziegler, B. K. Desai, Jo-Ann Jee, B. Gupton, T. Roper, T. Jamison   +5 more
semanticscholar   +1 more source

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry Reports
Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking
Nafiseh Karimi, Amirreza Dowlati Beirami, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi, Afshin Zarghi   +4 more
doaj   +1 more source

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule [PDF]

, 2009
HIV-1 integrase (IN) is a validated target for developing antiretroviral inhibitors. Using affinity acetylation and mass spectrometric (MS) analysis, we previously identified a tetra-acetylated inhibitor (2E)-3-[3,4-bis(acetoxy)phenyl]-2-propenoate-N ...
Burke, Terrence R., Jr., Eidahl, Jocelyn O., Hess, Sonja, Kessl, Jacques J., Kvaratskhelia, Mamuka, McKee, Christopher J., Shkriabai, Nikolozi, Zhao, Zhuojun   +7 more
core   +3 more sources

Weight Gain Associated with Integrase Stand Transfer Inhibitor Use in Women.

Clinical Infectious Diseases, 2019
BACKGROUND Integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is recommended for HIV management. Although studies have suggested associations between INSTIs and weight gain, women living with HIV (WLHIV) are underrepresented ...
A. Kerchberger, A. Sheth, Christine D. Angert, C. Mehta, N. Summers, I. Ofotokun, D. Gustafson, S. Weiser, Anjali Sharma, A. Adimora, A. French, M. Augenbraun, Jennifer Cocohoba, S. Kassaye, H. Bolivar, Usha Govindarajulu, D. Konkle-Parker, E. Golub, Cecile D. Lahiri   +18 more
semanticscholar   +1 more source

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 ...
Daria J Hazuda
doaj   +1 more source

Different Pathways Leading to Integrase Inhibitors Resistance [PDF]

Frontiers in Microbiology, 2017
Integrase strand-transfer inhibitors (INSTIs), such as raltegravir (RAL), elvitegravir, or dolutegravir (DTG), are efficient antiretroviral agents used in HIV treatment in order to inhibit retroviral integration. By contrast to RAL treatments leading to well-identified mutation resistance pathways at the integrase level, recent clinical studies report ...
Eloïse Thierry, Olivier Delelis, Eric Deprez   +2 more
openaire   +3 more sources

Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

PLoS Pathogens, 2017
The kinetics of HIV-1 decay under treatment depends on the class of antiretrovirals used. Mathematical models are useful to interpret the different profiles, providing quantitative information about the kinetics of virus replication and the cell ...
E. F. Cardozo, A. Andrade, J. Mellors, D. Kuritzkes, A. Perelson, R. Ribeiro, R. Ribeiro   +6 more
semanticscholar   +1 more source