Results 131 to 140 of about 3,561 (181)

Binding Mode Prediction of Strand Transfer HIV-1 Integrase Inhibitors Using Tn5 Transposase as a Plausible Surrogate Model for HIV-1 Integrase

, 2016
The crystal structure of Tn5 transposase−DNA complex was used in docking experiments to predict binding modes of HIV-1 integrase strand transfer inhibitors (INSTIs).
Alba Chimirri (76729), Nunzio Iraci (148416), Laura De Luca (76726), Maria Letizia Barreca (76727)   +3 more
core   +1 more source

Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond

, 2012
HIV-1 integrase is one of the three viral enzymes essential to HIV replication. Consequently the development of therapeutics targeting this enzyme has been a major focus of antiretroviral research over the past two decades.
Rutledge, P., Coster, MJ, Rutledge, PJ, Coster, Mark, Beare, KD, Beare, K.   +5 more
core   +1 more source

Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan

Scientific Reports
HIV acquisition has been found to be associated with increased risk of cardiometabolic syndrome in the past. In this study, we attempt to delineate the associated factors of metabolic syndrome among persons living with HIV in a single medical center in ...
Chien-An Tu, Chien-Feng Kuo, Chun-Ming Lee, Chang-Pan Liu, Hsiang-Kuang Tseng, Tseng-Yu Huang, Chih-Chen Lin, Hsun Chang, Winter Yu-Ning Lee, Fang-Ju Sun, Zu-Yi Sun, Pei-Ching Lian, Ming-Wei Cheng, Alice Ying-Jung Wu   +13 more
doaj   +1 more source

HIV Integrase Inhibitor [PDF]

, 2020
openaire   +1 more source

Therapeutic Opportunities in Infectious Diseases: Highlights from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, London, UK

, 2013
Collingwood, S P, Pryde, D C, Anderson, RJ, Collingwood, SP, Pryde, DC, Anderson, Rosaleen, Alderton, W K, Alderton, WK   +7 more
core  

Will Integrase Inhibitors be Used as Microbicides?

Current HIV Research, 2012
Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections including HIV-1. Despite more than two decades of HIV-1 research, there is still no efficacious HIV-1 vaccine, and the scientific community appears ...
CUZZUCOLI CRUCITTI, GIULIANA, Maurizio Botta, DI SANTO, Roberto   +2 more
openaire   +4 more sources

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Integrase inhibitors to treat HIV/Aids

Nature Reviews Drug Discovery, 2005
HIV integrase is a rational target for treating HIV infection and preventing AIDS. It took approximately 12 years to develop clinically usable inhibitors of integrase, and Phase I clinical trials of integrase inhibitors have just begun. This review focuses on the molecular basis and rationale for developing integrase inhibitors.
Yves Pommier, Allison A Johnson, Christophe Marchand   +2 more
exaly   +3 more sources

Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors [PDF]

Journal of Global Antimicrobial Resistance, 2020
Objectives: This study evaluated the emergence of mutations associated with integrase strand transfer inhibitors (INSTI) resistance (INSTI-RMs) and the integrase evolution in human immunodeficiency virus type 1 (HIV-1) infected patients treated with this
Rossana Scutari, Claudia Alteri, Ilaria Vicenti   +2 more
exaly   +3 more sources

Allosteric Integrase Inhibitors

, 2016
In the recent years, integrase (IN) has emerged as an important new target for the development of anti-HIV-1 agents. The enzyme is involved in a key stage of the retroviral replicative cycle, and interacts with a range of cellular co-factors.
Victoria Hann, Peter Dawson, Mark Ashton
openaire   +2 more sources

Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance

Bioorganic and Medicinal Chemistry, 2009
This study undertook an exploratory data analysis of the binding parameters of HIV-1 integrase inhibitors. The study group involved inhibitors in preclinical development from the diketo acid, pyrroloquinoline and naphthyridine carboxamide families and ...
Constantinos D Zeinalipour-Yazdi, Tasos C Christofides, Leondios G Kostrikis   +2 more
exaly   +3 more sources