Results 121 to 130 of about 3,561 (181)
, 2007 Integrase is actively studied as an antiviral target, but many inhibitors selected from biochemical screens fail to inhibit human immunodeficiency virus (HIV) replication or primarily affect off-site targets.
De Clercq, Erik +3 more
core +1 more source
A Natural LTR Retrotransposon Insertion in the Promoter of GhNAC140‐Dt Boosts Cotton Lint Yield
Plant Biotechnology Journal, Volume 24, Issue 6, Page 4240-4262, June 2026.ABSTRACT Transposable elements (TEs) are fundamental drivers of crop evolution and domestication. Whereas the underlying mechanisms of TE‐mediated gene activation remain poorly understood. Lint percentage is an important yield component in cotton. Here, we report a retrotransposon insertion in the promoter of GhNAC140‐Dt, a secondary wall NAC encoding ...
Yujia Yu +9 more
wiley +1 more source
Role of Integrase Acetylation in HIV-1 Replication Cycle and Search for Acetylation Inhibitors [PDF]
, 2013 HIV-1 integrase catalyzes the integration of the viral DNA into the genome of the host cells. This irreversible event is crucial to the pathogenesis of the infection and complicates its eradication both by the immune systems and by pharmacological ...
VALENTINI, PAOLA
core
, 2004 International audienceWe have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of action of these molecules.
Vita, Claudio +9 more
core +1 more source
Critical appraisal of elvitegravir in the treatment of HIV-1/AIDS
HIV/AIDS: Research and Palliative Care, 2014 Krishan K PandeyInstitute for Molecular Virology, Saint Louis University Health Sciences Center, St Louis, MO, USAAbstract: Human immunodeficiency virus type 1 (HIV-1) integrase inhibitors belong to a novel class of antiretroviral drugs with high potency
Pandey KK
doaj
Caffeoylquinic acids as inhibitors for HIV-I protease and HIV-I integrase: a molecular docking study [PDF]
, 2016 Caffeoylquinic acids are ubiquitous phenolic compounds with several health benefits to humans and they have been shown to be promisinganti-HIV compounds.
Castilho, Paula C. +2 more
core
Pharmacophore-Based Design of HIV-1 Integrase Strand-Transfer Inhibitors
, 2016 Using a training set of diketo-like acid HIV-1 integrase (IN) strand-transfer inhibitors, a 3D pharmacophore model was derived having quantitative predictive ability in terms of activity.
Alba Chimirri (76729) +8 more
core +1 more source
Inhibitors of HIV-1 integrase from Dioscorea bulbifera [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2016 A search for HIV-1 integrase (IN) inhibitors from natural sources has led to the isolation of compounds from Dioscorea bulbifera bulbils. From the bioassay-guided isolation, the chloroform fraction was then fractionated to obtain one new clerodane ...
Prapaporn Chaniad +3 more
doaj
4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells
, 2016 4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in ...
Lori J. Gabryelski (3010656) +20 more
core +1 more source
Ruthenium arene complexes as HIV-1 integrase strand transfer inhibitors
, 2013 The quinolone HL1 and the hydroxypyrimidine-carboxamide HL2 were designed and synthesized as models of the HIV integrase strand transfer inhibitors Elvitegravir and Raltegravir (brand name Isentress), with the aim to study their complexing behavior and ...
Bacchi, Alessia +11 more
core +1 more source