Results 101 to 110 of about 3,561 (181)

A Global Health Alert on the Re‐Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Muslim Bin Aqeel, Asif Hanif, Shahzad Ahmad, Fatima Iftikhar Shah, Benish Javed, Shazia Iqbal   +5 more
wiley   +1 more source

Potential benefit of dolutegravir once daily: efficacy and safety

HIV/AIDS: Research and Palliative Care, 2013
Alessandra Fantauzzi,1 Ombretta Turriziani,2 Ivano Mezzaroma11Department of Clinical Medicine, 2Department of Molecular Medicine, Sapienza, University of Rome, Rome, ItalyAbstract: The viral integrase enzyme has recently emerged as a primary alternative ...
Fantauzzi A, Turriziani O, Mezzaroma I
doaj  

Timely and Efficient Infant Diagnosis Is Required to End AIDS in Children

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Though considerable effort and investment has significantly increased the proportion of pregnant women living with HIV accessing lifesaving antiretroviral therapy and lowered the prevalence of vertical HIV transmission, more than 70,000 children die each year due to AIDS‐related deaths, and nearly half of the 1.4 million children ...
Lara Vojnov, Ilesh V. Jani
wiley   +1 more source

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

, 2004
The increasing incidence of resistance to current HIV-1 therapy underscores the need to develop antiretroviral agents with new mechanisms of action.
Stillmock, Espeseth, Summa V, Huff, J R., Ellis, Pearson, N J., Grobler, PG., Zhuang, Wong, Guare, Xu, Holloway, D J., Embrey, K A., Kassahun, J D., WA., JP., Witmer, Egbertson, Jolly, Miller, S D, AS., Wai, M D., Vacca, Felock, Cortese, E, Gomez, Jr., S M., R P., J, K, L, M, M S., Chen, Schleif, M. K, R, I-W, Fisher, J P., W, J H., Danovich, Young, Emini, Anthony, M V., Jin, Lin, J S., T E., PJ., Hazuda, B K.   +63 more
core   +1 more source

Baseline Data on Viral Suppression, Treatment Adherence and Mental Health in Peripartum Girls and Young Women With HIV in Zimbabwe

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir‐based regimens and psychosocial peer motivation may improve viral control.
Tariro D. Chawana‐Mutingwende, Bernard Ngara, Leon‐Say Mudadi, Thelma T. Tauya, Marvelous Sibanda, Mercy Mutambanengwe‐Jacob, Precious Andifasi, Bernadette Malunda, Tinashe Chidemo, Annie Mapfunde, Sandra Nyakudya, Anna Z. Mufumisi, Thandiwe H. Chirenda, Tobias Chitambo, Walter T. S. Nderecha, Constance Murandu, Miriam Gwande, Kudakwashe Muringayi, Rhoda Micah Bongo, Hideaki Okochi, Karen Kuncze, Angela Mushavi, Nicola Willis, Karen Webb, Monica Gandhi, Lynda Stranix‐Chibanda   +25 more
wiley   +1 more source

Cause of Death and Risk of Death for People Living With HIV Admitted to Hospital: A Systematic Review and Meta‐Analysis

Journal of the International AIDS Society, Volume 29, Issue 6, June 2026.
ABSTRACT Introduction Despite increasing access to HIV treatment and care, HIV‐associated deaths remain high. We aimed to summarize global and regional trends in risk and causes of death among people living with HIV (PLHIV) admitted to hospital. Methods We conducted a systematic search across eight databases on 23 April 2023, identifying studies that ...
Rachael M. Burke, Nadia Sabet, Jayne Ellis, Hannah M. Rickman, Ajay Rangaraj, David S. Lawrence, Joseph N. Jarvis, Jane Falconer, Lillian Tugume, Rebecca H. Berhanu, Nathan Ford, Peter MacPherson   +11 more
wiley   +1 more source

Retrovirus-based pseudotyped virus neutralisation assays overestimate neutralising activity in sera from participants receiving integrase inhibitors

Scientific Reports
Retroviral pseudotype-based virus neutralisation assays are widely used to estimate functional immunity, but may be unsuitable for testing human immunodeficiency virus (HIV)-infected individuals receiving integrase inhibitor treatment. We evaluated these
Mhairi J. McCormack, Patawee Asamaphan, Ellen C. Hughes, Louis Banda, Stephen Kasenda, Chris Davis, Agnieszka M. Szemiel, Amelia Crampin, Abena S. Amoah, Emma C. Thomson, Antonia Ho, Brian J. Willett   +11 more
doaj   +1 more source

Isolation of New Chemical Modulators of the Interaction Between HIV-1 Integrase and the Cellular Restriction Factor GCN2

Viruses
Integrase is a key protein during HIV-1 replication as it catalyzes the integration of viral DNA into the host DNA. After several decades of research, highly potent and selective active site inhibitors have emerged.
Chloé Torres, Floriane Lagadec, Eugenia Basyuk, Patricia Recordon-Pinson, Mathieu Métifiot   +4 more
doaj   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

HIV-1 Integrase Inhibitors

Drugs in R & D, 2007
From the discovery of HIV-1 integrase (IN) inhibitors using enzyme-based assays in 1992, it has taken 15 years to achieve success in human clinical trials. Currently available antiretroviral drugs set high clinical standards in efficacy and long-term safety for upcoming novel HIV/AIDS therapeutic agents.
Raveendra, Dayam, Laith Q, Al-Mawsawi, Nouri, Neamati   +2 more
openaire   +2 more sources