Results 81 to 90 of about 3,561 (181)

Prior PrEP use and discontinuation in individuals newly diagnosed with HIV

HIV Medicine, EarlyView.
Abstract Background In settings with high uptake of HIV pre‐exposure prophylaxis (PrEP), an increasing proportion of individuals newly diagnosed with HIV report prior PrEP exposure. Understanding patterns of PrEP use, discontinuation and adherence in such settings is essential to inform future HIV prevention strategies.
Rohan Saini, Sarah Fidler, Marta Boffito, Vicky Tittle, Nicolo Girometti, Gary Whitlock, on behalf of the Dean Street Collaborative Group, Keerti Gedela, Franki Lander, Alan McOwan, Diarmuid Nugent, Sheel Patel, Sashini Payagala, Tara Suchak, Vicky Tittle, Gary Whitlock   +15 more
wiley   +1 more source

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

, 2012
An attenuation of the HIV-1 replication capacity (RC) has been observed for immune-mediated escape mutations in Gag restricted by protective HLA alleles.
Olvera, A., Markle, T.J., Cheung, P.K., John, M., Brumme, Z.L., Brumme, C.J., Carlson, J.M., Kelleher, A.D., Markowitz, M., Frahm, N., McGovern, R., Harrigan, P.R., Brander, C., Heckerman, D., Sanchez, J., Walker, B.D., Chopera, D.R., Sela, J., Le, A.Q., Jessen, H., Martin, E., Rosenberg, E., Brockman, M.A., Mallal, S.   +23 more
core  

Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2

Viruses
Retroviruses perpetuate their survival by incorporating a copy of their genome into the host cell, a critical step catalyzed by the virally encoded integrase.
Irene Wanjiru Kiarie, Gyula Hoffka, Manon Laporte, Pieter Leyssen, Johan Neyts, József Tőzsér, Mohamed Mahdi   +6 more
doaj   +1 more source

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

eLife, 2019
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN.
Pratibha C Koneru, Ashwanth C Francis, Nanjie Deng, Stephanie V Rebensburg, Ashley C Hoyte, Jared Lindenberger, Daniel Adu-Ampratwum, Ross C Larue, Michael F Wempe, Alan N Engelman, Dmitry Lyumkis, James R Fuchs, Ronald M Levy, Gregory B Melikyan, Mamuka Kvaratskhelia   +14 more
doaj   +1 more source

Screening for bone health in older people with HIV: Uptake and outcomes from a large UK outpatient HIV service

HIV Medicine, EarlyView.
Abstract Objectives Bone health is negatively affected in people with HIV, and the risks of osteoporosis and fragility fractures are increased. The objective of this study was to describe the characteristics of those accessing bone health screening and identify factors associated with osteoporosis.
Rhys Nicholas, Kate Alford, Colin Fitzpatrick, Jaime Vera   +3 more
wiley   +1 more source

Development of a phenotypic susceptibility assay for HIV-1 integrase inhibitors

, 2016
Phenotypic resistance analysis is an indispensable method for determination of HIV-1 resistance and cross-resistance to novel drug compounds. Since integrase inhibitors are essential components of recent antiretroviral combination therapies, phenotypic ...
Pironti, A., Knops, Elena, Remmel, Klaus, Pironti, Alejandro, Theis, A., Knops, E., Esser, Stefan, Theis, Alexandra Andrée, Jensen, B., Walter, H., Jensen, Björn, Lübke, Nadine, Walter, Hauke, Cristanziano, V., Kaiser, R., Kaiser, Rolf, Lübke, N., Heger, E., Di Cristanziano, Veronica, Esser, S., Remmel, K., Heger, Eva   +21 more
core   +1 more source

Brief Histories of Retroviral Integration Research and Associated International Conferences

Viruses
The field of retroviral integration research has a long history that started with the provirus hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase enzymes.
Duane P. Grandgenett, Alan N. Engelman
doaj   +1 more source

Interactions of Host Proteins with the Murine Leukemia Virus Integrase

Viruses, 2010
Retroviral infections cause a variety of cancers in animals and a number of diverse diseases in humans such as leukemia and acquired immune deficiency syndrome.
Barbara Studamire, Stephen P. Goff
doaj   +1 more source

Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

mBio, 2020
Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is ...
Ishak D. Irwan, Heather L. Karnowski, Hal P. Bogerd, Kevin Tsai, Bryan R. Cullen   +4 more
doaj   +1 more source

Long‐Acting Cabotegravir/Rilpivirine Reduces Immune‐Activation and ‐Senescence in People With HIV With CMV Co‐Infection

Immunology, EarlyView.
This study investigates the impact of switching to long‐acting (LA) injectable cabotegravir and rilpivirine (CAB/RPV‐LA) on immune‐activation and ‐senescence in people with HIV (PWH). Thirty‐seven PWH switching to CAB/RPV‐LA and nine continuing oral ART were analysed over 72 weeks. LA therapy led to significant reductions in activation T and senescence
Mariasilvia Guardiani, Eeva Tortellini, Anna Carraro, Maria Antonella Zingaropoli, Lorenzo Ansaldo, Alessandra Grimaldi, Serena Vita, Federica Dominelli, Fabio Mengoni, Caterina Pasquazzi, Ombretta Turriziani, Maria Rosa Ciardi, Vincenzo Vullo, Claudio Maria Mastroianni, Raffaella Marocco, Cosmo Del Borgo, Miriam Lichtner   +16 more
wiley   +1 more source