Results 91 to 100 of about 633,523 (228)

Potential benefit of dolutegravir once daily: efficacy and safety

HIV/AIDS: Research and Palliative Care, 2013
Alessandra Fantauzzi,1 Ombretta Turriziani,2 Ivano Mezzaroma11Department of Clinical Medicine, 2Department of Molecular Medicine, Sapienza, University of Rome, Rome, ItalyAbstract: The viral integrase enzyme has recently emerged as a primary alternative ...
Fantauzzi A, Turriziani O, Mezzaroma I
doaj  

Allosteric Integrase Inhibitors

, 2016
In the recent years, integrase (IN) has emerged as an important new target for the development of anti-HIV-1 agents. The enzyme is involved in a key stage of the retroviral replicative cycle, and interacts with a range of cellular co-factors.
Ashton, Mark, Hann, Victoria, Dawson, Peter   +2 more
core   +1 more source

HIV viral suppression in children and adolescents who transitioned from ritonavir‐boosted lopinavir‐ to dolutegravir‐based antiretroviral therapy in Lesotho

HIV Medicine, EarlyView.
Abstract Objectives Children and adolescents living with HIV previously taking ritonavir‐boosted lopinavir (LPV/r)‐based antiretroviral therapy (ART) have been programmatically transitioned to dolutegravir (DTG)‐based regimens in many country programs.
Jacob Blankenberger, Teresa L. F. Steffy, Tristan Lee, Thithili Makhesi, Meenakshi Bakaya, Akash Devendra, Pheello Mothepu, Lipontso Motaboli, Nadine Tschumi, Anna Klicpera, Tapiwa Tarumbiswa, Frédérique Chammartin, Lineo K. Thahane, Niklaus D. Labhardt, Jennifer A. Brown   +14 more
wiley   +1 more source

A systematic review of evidence on weight change following initiation of long‐acting cabotegravir for the prevention or treatment of HIV

HIV Medicine, EarlyView.
Abstract Background Weight gain is an increasingly recognized concern among people receiving antiretroviral therapy (ART) and may increase the risk of non‐communicable diseases. Integrase inhibitors (INSTIs) such as dolutegravir (DTG) have been associated with weight gain, but the metabolic effects of long‐acting cabotegravir (CAB‐LA), another INSTI ...
Jonathan Kitonsa, Ronald Komata, Wilber Ssembajjwe, Daniel Grint, Julian Robinson, Eugene Ruzagira, Robert Kalyesubula, Jaime Vera, Fiona Cresswell   +8 more
wiley   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

Isolation of New Chemical Modulators of the Interaction Between HIV-1 Integrase and the Cellular Restriction Factor GCN2

Viruses
Integrase is a key protein during HIV-1 replication as it catalyzes the integration of viral DNA into the host DNA. After several decades of research, highly potent and selective active site inhibitors have emerged.
Chloé Torres, Floriane Lagadec, Eugenia Basyuk, Patricia Recordon-Pinson, Mathieu Métifiot   +4 more
doaj   +1 more source

Characterization of a Replication-Competent, Integrase-Defective Human Immunodeficiency Virus (HIV)/Simian Virus 40 Chimera as a Powerful Tool for the Discovery and Validation of HIV Integrase Inhibitors

, 2019
Integrase is actively studied as an antiviral target, but many inhibitors selected from biochemical screens fail to inhibit human immunodeficiency virus (HIV) replication or primarily affect off-site targets.
De Clercq, Erik, Lu, Richard, Daelemans, Dirk, Engelman, Alan   +3 more
core   +1 more source

Development of a Multiplex Polymerase Chain Reaction Assay for Differentiating Three Lactococcus Species Associated With Piscine Lactococcosis

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscine lactococcosis is an important bacterial disease of farmed fish. The causative agents, Lactococcus garvieae, Lactococcus petauri and Lactococcus formosensis, are closely related, which complicates species‐level identification. We developed a conventional multiplex PCR assay targeting species‐specific genes identified by comparative ...
Tomoaki Yoshino, Tomokazu Takano, Hiroki Tanno, Yukihiro Nakagawa, Yuta Matsuura, Shogo Harakawa, Hidehiro Kondo, Ikuo Hirono, Keiichiro Koiwai, Tomomasa Matsuyama   +9 more
wiley   +1 more source

Structure–Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors

, 2016
Integration of human immunodeficiency virus type 1 DNA into an infected cell genome is one of the key steps of the viral replication cycle. Therefore, viral enzyme integrase, which realizes the integration, represents an attractive and validated target ...
Julia Agapkina (411356), Timofei Zatsepin (2183124), Jean-Francois Mouscadet (2183122), Marina Gottikh (411363), Ekaterina Knyazhanskaya (2183120)   +4 more
core   +1 more source