Results 91 to 100 of about 3,561 (181)

Characterization of a Replication-Competent, Integrase-Defective Human Immunodeficiency Virus (HIV)/Simian Virus 40 Chimera as a Powerful Tool for the Discovery and Validation of HIV Integrase Inhibitors

, 2019
Integrase is actively studied as an antiviral target, but many inhibitors selected from biochemical screens fail to inhibit human immunodeficiency virus (HIV) replication or primarily affect off-site targets.
De Clercq, Erik, Lu, Richard, Daelemans, Dirk, Engelman, Alan   +3 more
core   +1 more source

HIV-1 Genetic Diversity and Natural Polymorphisms of the Integrase Gene in Integrase Inhibitor-Naive Patients in Harare, Zimbabwe.

, 2021
Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have become part of the preferred antiretroviral therapy (ART) first-line regimen in most low- to middle-income countries. With the extensive use of dolutegravir in
Manasa, Justen, Shamu, Tinei, Kouamou, Vinie, Katzenstein, David, Dhoro, Milcah, Madyadi, Amanda, Washaya, Tendai, Chimukangara, Benjamin   +7 more
core   +1 more source

HIV Care Retention and Cost Analysis in Multi‐Month ART Dispensing: A Randomized Controlled Trial in China

Journal of the International AIDS Society, Volume 29, Issue 7, July 2026.
ABSTRACT Introduction Multi‐month dispensing (MMD), as a differentiated service delivery model, can reduce the frequency of clinic visits, waiting time and travel costs for clinically stable people living with HIV. This study aimed to evaluate the impact of 6‐month MMD of antiretroviral therapy (ART) on retention and conduct a cost analysis in China ...
Wenqi Shang, Yanyan Zhu, Ying He, Xiaolin Li, Qinghai Hu, Hong Sun, Wenqing Geng, Hong Shang, Haibo Ding   +8 more
wiley   +1 more source

Structure–Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors

, 2016
Integration of human immunodeficiency virus type 1 DNA into an infected cell genome is one of the key steps of the viral replication cycle. Therefore, viral enzyme integrase, which realizes the integration, represents an attractive and validated target ...
Julia Agapkina (411356), Timofei Zatsepin (2183124), Jean-Francois Mouscadet (2183122), Marina Gottikh (411363), Ekaterina Knyazhanskaya (2183120)   +4 more
core   +1 more source

Affinity Proteomics‐Based Non‐Invasive Detection of Clinically Significant Liver Disease

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 74-88, July 2026.
Using UK Biobank proteomic data, we identified a five‐protein score reflecting hepatic stellate cell activation and hepatocellular injury that predicts major adverse liver outcomes and clinically significant fibrosis, with consistent performance validated in two independent cohorts (patients with HIV and alpha1‐antitrypsin deficiency).
Sriram Balasubramani, Katharina Remih, Anna Sophie Karl, Julia Alexandra Borchert, Christina Schrader, Malin Fromme, Can Kayatekin, Bailin Zhang, Mikhail Levit, Pavithra Krishnaswami, Louise E. van Eekeren, Leo A. B. Joosten, Twan Otten, Petra Tomanová, Pavel Strnad   +14 more
wiley   +1 more source

Nickel Photocatalytic Access to β‐Arylated β‐Amino Acids

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Converting naturally abundant amino acids to non‐canonical derivatives in one step under mild conditions allows for improved pharmaceutical properties. Now, this is achieved for β‐arylated β‐amino acids, which are available in good yields directly from aspartic acid, and have the potential to become platform chemicals for drug discovery.
Tim S. Stamp, Ning Wei, Laura K. C. Zedelmair, Sebastian B. Beil   +3 more
wiley   +1 more source

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

Molecules, 2018
HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions ...
Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques J. Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke   +8 more
doaj   +1 more source

Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub‐Saharan Africa

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Introduction Congenital anomalies (CA) are ranked as the 3rd and 4th leading cause of neonatal and under‐5 mortality, respectively. Over 30% of infants born with a serious CA are found in sub‐Saharan Africa. Yet there are few robust epidemiological data on the burden and distribution of CA and associated mortality, disability, and morbidity ...
Emma Kalk, Helen Louise Malherbe, Ushma C. Mehta, Daniel Mumpe‐Mwanja, Modiegi Dianah Diseko, Adejumoke Idowu Ayede, Phyllis Kisa, Caroline Bonareri Osoro, George Bello, Lee Fairlie, Audrey Chepkemoi, Hamisi K. Shabani, Ali Sie, Samrawit Abebaw Tegene, Robert Serunjogi, Aminkeng Zawuo Leke, Helen Dolk, Linda Barlow Mosha, on behalf of the sub‐Saharan African Congenital Anomalies Network (sSCAN)   +18 more
wiley   +1 more source

HIV - recentes avanços na pesquisa de fármacos HIV - highlights in drug research

Química Nova, 2008
The development of new antiretroviral drugs is a dynamic process that is continuously fueled by identification of new molecular targets and new compounds for know targets.
Wilson Cunico, Claudia R. B. Gomes, Walcimar T. Vellasco Junior   +2 more
doaj   +1 more source

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source