Results 171 to 180 of about 2,882,240 (203)

Advances in the development of HIV integrase strand transfer inhibitors

European Journal of Medicinal Chemistry, 2021
HIV-1 integrase (IN) is a key enzyme in viral replication that catalyzes the covalent integration of viral cDNA into the host genome. Currently, five HIV-1 IN strand transfer inhibitors (INSTIs) are approved for clinical use. These drugs represent an important addition to the armamentarium for antiretroviral therapy. This review briefly illustrates the
Yue, Wang, Shuang-Xi, Gu, Qiuqin, He, Renhua, Fan   +3 more
openaire   +2 more sources

Impact of Integrase Strand Transfer Inhibitors on Cognition in the HAILO Cohort

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2023
Background: Integrase inhibitors (INSTIs) have been associated with poorer cognition in people with HIV (PWH). We examined the impact of switching to INSTIs on neuropsychological (NP) outcomes in PWH 40 years of age and older.
Jane A. O'Halloran, Luis Parra-Rodriguez, Charles W. Goss, Mansi Agarwal, Sarah Cooley, Kunling Wu, Elizabeth Westerhaus, Rachel Presti, Beau M. Ances, Katherine Tassiopoulos, Kristine M. Erlandson   +10 more
openaire   +2 more sources

Drug safety profile of integrase strand transfer inhibitors

Expert Opinion on Drug Safety, 2014
HIV-1 integrase strand transfer inhibitors (INSTIs) are a novel class of antiretroviral drugs with a good safety profile. Several INSTIs have been developed clinically.The purpose of this review is to examine the safety data of the three FDA-approved INSTIs: Raltegravir (RAL), Elvitegravir (EVG) and Dolutegravir (DTG).
Maria del Mar, Gutierrez, Maria Gracia, Mateo, Francesc, Vidal, Pere, Domingo   +3 more
openaire   +4 more sources

The Use of Integrase Strand Transfer Inhibitors to Treat HIV in Pregnancy

Journal of Midwifery & Women's Health, 2021
AbstractFor pregnant women with HIV, antiretroviral therapy (ART) plays a key role in prevention of perinatal transmission. Newer antiretroviral regimens now contain integrase strand transfer inhibitors, which have been found to rapidly suppress HIV viral load in nonpregnant women; however, there are limited data for use in pregnancy.
Oriel Nissim, Gweneth B. Lazenby
openaire   +2 more sources

Targeting HIV-1 integrase with strand transfer inhibitors

Drug Discovery Today, 2015
HIV-1 integrase (IN) is a retroviral enzyme essential for integration of genetic material into the DNA of the host cell and hence for viral replication. The absence of an equivalent enzyme in humans makes IN an interesting target for anti-HIV drug design. This review briefly overviews the structural and functional properties of HIV-1 IN. We analyze the
Yang, Li, Shouyi, Xuan, Yue, Feng, Aixia, Yan   +3 more
openaire   +2 more sources

Increase in visceral adipose tissue in a woman living with HIV after introduction of integrase strand transfer inhibitor

International Journal of STD and AIDS, 2020
Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between ...
Sebastiano Rizzardo, Massimiliano Lanzafame, Giulia Zamboni   +2 more
exaly   +2 more sources

Adverse drug reactions to integrase strand transfer inhibitors

AIDS, 2018
To describe and compare integrase strand transfer inhibitor (INSTI) adverse drug reactions (ADRs) for raltegravir, elvitegravir-cobicistat, and dolutegravir.Population-based, retrospective cohort.Antiretroviral-experienced and naive persons at least 19 years old were included if they received their first prescription for raltegravir, elvitegravir ...
Katherine J, Lepik, Benita, Yip, Ana C, Ulloa, Lu, Wang, Junine, Toy, Linda, Akagi, Viviane Dias, Lima, Silvia, Guillemi, Julio S G, Montaner, Rolando, Barrios   +9 more
openaire   +2 more sources