Results 181 to 190 of about 2,882,240 (203)
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Update on Raltegravir and the Development of New Integrase Strand Transfer Inhibitors
Southern Medical Journal, 2012Raltegravir (RAL) is the first antiretroviral in the integrase strand transfer inhibitors (INSTI) class. The use of RAL has expanded since its approval in October 2007 for multidrug-resistant human immunodeficiency virus type 1 infection in adults.
Caitlin Lee, Shamroe +3 more
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The Promise of Dolutegravir: A Novel Second Generation Integrase Strand Transfer Inhibitor
Current Clinical Pharmacology, 2016Dolutegravir (DTG), a novel integrase strand transfer inhibitor (INSTI), is one of the newest addition to the arsenal of anti-human immunodeficiency virus (HIV) therapeutics. Dolutegravir is the first member of the class of second generation integrase strand transfer inhibitors aimed primarily to address the current unmet need for novel unboosted ...
Ashish Kumar Kakkar
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Dolutegravir: A new integrase strand transfer inhibitor for the treatment of
The first two integrase strand transfer inhibitors ( INSTI s) approved for treatment of patients infected with human immunodeficiency virus ( HIV) were raltegravir and elvitegravir. Both raltegravir and elvitegravir are now guideline‐preferred agents as
Bhavik M, Shah +2 more
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HIV-1 Integrase Strand Transfer Inhibitors
2010Publisher Summary This chapter focuses on a new class of antiretroviral agents called “integrase (IN) strand transfer inhibitors” that exert their pharmacological effect by preventing the incorporation of viral DNA into host chromatin. The evolution of HIV-1IN strand transfer inhibitors has been one of the most significant advances in the field of ...
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Chromone and chromanone derivatives as strand transfer inhibitors of HIV-1 integrase
Archives of Pharmacal Research, 2008HIV-1 integrase catalyzes terminal cleavage at the 3' end of the proviral DNA, removing a pair of bases and causing strand transfer by joining the 3' end to 5'-phosphates in the target DNA. Several aryl 1,3-diketo acids that can inhibit the strand transfer reaction of HIV-1 IN have been identified.
Jang Hyun, Park +7 more
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Integrase strand transfer inhibitor-associated diabetes mellitus: A case report
International Journal of STD & AIDS, 2016Integrase strand transfer inhibitors (INSTIs) have become integral antiretroviral therapy (ART) agents for treating HIV infection. We report the case of a 44-year-old male with a history of hemophilia A who developed diabetes mellitus four months after switching from abacavir, lamivudine, and efavirenz to abacavir, lamivudine, and raltegravir ...
Peter S, Fong +3 more
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Emergent drug resistance with integrase strand transfer inhibitor-based regimens
AIDS, 2017To estimate the incidence of and risk factors for emergent resistance to integrase strand transfer inhibitor (INSTI) and nucleoside(-tide) reverse transcriptase inhibitors (NRTI) in HIV-1-infected adults receiving an INSTI and two NRTIs.Retrospective cohort study.Persons aged at least 19 years were included if they received their first prescription for
Katherine J, Lepik +11 more
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Genotypic correlates of resistance to the HIV-1 strand transfer integrase inhibitor cabotegravir
Antiviral Research, 2022Soo-Yon Rhee, Robert W. Shafer
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