Results 101 to 110 of about 2,862,567 (165)

Mutational analysis of PhiC31 integrase to improve gene therapeutic applications [PDF]

, 2010
Die Bakteriophagen Integrase PhiC31 stellt ein viel versprechendes Werkzeug zur Integration genetischen Materials im nicht viral-basierten Gentransfer dar.
Liesner, Raphael
core   +1 more source

Profile of bictegravir/emtricitabine/tenofovir alafenamide fixed dose combination and its potential in the treatment of HIV-1 infection: evidence to date

HIV/AIDS: Research and Palliative Care, 2018
Lucas Hill,1 Shawn R Smith,1 Maile Young Karris2 1University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, USA; 2Department of Medicine, University of California San Diego, San Diego, CA, USA Abstract ...
Hill L, Smith SR, Karris MY
doaj  

Structure-guided optimization of HIV integrase strand transfer inhibitors

, 2020
Integrase mutations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer inhibitors (INSTIs), raltegravir (RAL) and elvitegravir (EVG).
Mathieu Métifiot (9514667), Valerie E Pye (8128395), Christophe Marchand (43010), Terrence R Burke (9449126), Peter Cherepanov (369), Katherine Fesen (1397647), Daniel P Maskell (8307387), Xue Zhi Zhao (1397659), Yves Pommier (11158), Stephen H Hughes (9449123), Steven J Smith (9449120)   +10 more
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Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China

Drug Design, Development and Therapy, 2021
Jinglan Lai, Yuming Liu, Xiao Han, Aiqiong Huang, Jin Lin, Wen Ao, Hanhui Ye, Yahong Chen Department of Infectious Diseases, Mengchao Hepatobiliary Hospital of Fujian Medical University, Infectious Diseases Hospital of Fuzhou, Fuzhou, Fujian, People ...
Lai J, Liu Y, Han X, Huang A, Lin J, Ao W, Ye H, Chen Y   +7 more
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HIV-1 non-group M phenotypic susceptibility to integrase strand transfer inhibitors

, 2017
International audienceObjectivesTo determine natural phenotypic susceptibility of non-group M HIV-1 to integrase strand transfer inhibitors (INSTIs) in a large panel of 39 clinical strains from groups O, N and P and to identify genotypic polymorphisms ...
A. Tourneroche, Unal, G., J. C. Plantier, Charpentier, C., Plantier, J., M. Bertine, M. Leoz, Bertine, M., Alessandri-Gradt, E., Tourneroche, A., G. Collin, E. Alessandri-Gradt, D. Descamps, Collin, G., C. Charpentier, G. Unal, Leoz, M., Descamps, D.   +17 more
core   +1 more source

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

, 2000
Integrase is essential for human immunodeficiency virus–type 1 (HIV-1) replication; however, potent inhibition of the isolated enzyme in biochemical assays has not readily translated into antiviral activity in a manner consistent with inhibition of ...
Carol Blau, Daria J. Hazuda, Marc Witmer, Jay A. Grobler, Peter Felock, Michael D. Miller, Abigail Wolfe, Amy Espeseth, Lori Gabryelski, William Schleif, Kara Stillmock   +10 more
core   +1 more source

Physical Trapping of HIV-1 Synaptic Complex by Different Structural Classes of Integrase Strand Transfer Inhibitors

, 2016
Raltegravir is an FDA approved inhibitor directed against human immunodeficiency virus type 1 (HIV-1) integrase (IN). In this study, we investigated the mechanisms associated with multiple strand transfer inhibitors capable of inhibiting concerted ...
Ajaykumar C. Vora (381421), Duane P. Grandgenett (381422), Krishan K. Pandey (381419), Sibes Bera (381420)   +3 more
core   +1 more source

HIV-1 Integrase Drug Discovery Comes of Age

, 2014
Insertion of the viral genome into host cell chromatin is a pivotal step in the replication cycle of the human immunodeficiency virus and other retroviruses.
Zeger Debyser, Demeulemeester, Jonas, Debyser, Zeger, Marc De Maeyer, De Maeyer, Marc, Jonas Demeulemeester   +5 more
core   +1 more source

Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV

Drug Design, Development and Therapy, 2015
Christopher E Kandel,1 Sharon L Walmsley1,21Department of Medicine, University of Toronto, Toronto, ON, Canada; 2Division of Infectious Diseases, University Health Network, Toronto, ON, CanadaAbstract: Dolutegravir is the newest integrase strand transfer
Kandel CE, Walmsley SL
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Confronting Dual Therapeutic Hurdles in Advanced HIV: A Case Report on INSTIs Resistance and Talaromyces marneffei Coinfection

International Medical Case Reports Journal
Lun Zou, Yuting Diao, Zhihao Huang, Chunfang You Department of Infectious Diseases, Zigong First People’s Hospital, Zigong, Sichuan, People’s Republic of ChinaCorrespondence: Chunfang You, Department of Infectious Diseases, Zigong First People’s Hospital,
Zou L, Diao Y, Huang Z, You C
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