Results 81 to 90 of about 2,862,567 (165)

From protease inhibitors to integrase strand transfer inhibitors: the evolution of HIV drug resistance management

Zhongguo linchuang yanjiu
Antiretroviral therapy (ART) has significantly improved the prognosis of HIV/AIDS patients and has become an important global strategy for the prevention and control of AIDS.
HU Zhiliang, YANG Yongfeng
doaj   +1 more source

Multifaceted Suppression of Staphylococcal Virulence Phenotypes: In Vitro Study of a Cellular Status With Reduced Agr Activity and Impaired Biofilm

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Finding of in vitro S. aureus status with reduced Agr activity and impaired biofilm. ABSTRACT Anti‐quorum sensing (QS) therapy has been focused on to reduce the virulence of pathogenic bacteria. However, there is a risk that suppression of the staphylococcal QS Agr system might promote biofilm formation.
Nghi Bao Nguyen, Yuri Ushijima, Raiku Sekiya, Kazuya Morikawa, Le Thuy Thi Nguyen   +4 more
wiley   +1 more source

Inhibition of HTLV-1 Infection by HIV-1 First- and Second-Generation Integrase Strand Transfer Inhibitors

Frontiers in Microbiology, 2019
More than 10 million people worldwide are infected with the retrovirus human T-cell lymphotropic virus type 1 (HTLV-1). Infection phenotypes can range from asymptomatic to severe adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy ...
Michał S. Barski, Jordan J. Minnell, Goedele N. Maertens   +2 more
doaj   +1 more source

Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA‐Enhanced Antibiofilm Activity

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq, Zac Newland‐Smith, Martin Figgit, David Lee, Kwabena Duedu   +4 more
wiley   +1 more source

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

Molecules, 2018
HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions ...
Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques J. Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke   +8 more
doaj   +1 more source

Population Pharmacokinetics of Dolutegravir in Plasma and Cerebrospinal Fluid in Adults Living With HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Characterizing dolutegravir penetration into the central nervous system is important for optimizing human immunodeficiency virus treatment outcomes, yet population‐specific pharmacokinetic data describing cerebrospinal fluid disposition and equilibration kinetics remain lacking.
Mohammed W. Ali, Sam Nightingale, Tracy Kellermann, John Joska, Alan Winston, Saye Khoo, Joseph F. Standing, Eric H. Decloedt, Ahmed A. Abulfathi   +8 more
wiley   +1 more source

Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of β-Diketo Acids

Molecules, 2015
HIV integrase, encoded at the 3′-end of the HIV pol gene, is essential for HIV replication. This enzyme catalyzes the incorporation of HIV DNA into human DNA, which represents the point of “no-return” in HIV infection.
Vasu Nair, Maurice Okello
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Thymic Involution and Function in People With HIV and General Population Controls: A Cross‐Sectional Analysis From Two Danish Cohort Studies

Aging Cell, Volume 25, Issue 10, October 2026.
Thymic involution, the age‐related replacement of thymic soft tissue by fat, has been linked to immunosenescence and chronic inflammation. Whether HIV infection affects thymic involution remains unclear. We found that people with HIV on long‐term antiretroviral therapy had more thymic tissue than controls, indicating less thymic involution. More thymic
Manon C. Vanbellinghen, Anders Boyd, Andreas Ohrt Johansen, Moises Alberto Suarez‐Zdunek, Andreas Dehlbæk Knudsen, Thomas Skårup Kristensen, Jørgen Tobias Kühl, Per Ejlstrup Sigvardsen, Michael Huy Cuong Pham, Andreas Fuchs Larsen, Klaus Fuglsang Kofoed, Børge Grønne Nordestgaard, Shoaib Afzal, Neeltje Kootstra, Susanne Dam Nielsen, Peter Reiss   +15 more
wiley   +1 more source

UltRaSoUnd‐guided evaLuAtion of metabolic health in a cohort of midlife women with HIV: The URSULA study

HIV Medicine, Volume 27, Issue 10, Page 1650-1662, October 2026.
Abstract Objectives We aimed to determine the prevalence of metabolic disorders, liver steatosis and metabolic dysfunction‐associated steatotic liver disease (MASLD) in a cohort of middle‐aged women with HIV (WoWH) and to explore associations between liver steatosis, visceral fat depots and carotid atherosclerosis.
Mariacristina Poliseno, Davide Capruzzi, Antonio Cianciaruso, Nicola Colavito, Felicia Dalitto, Vincenzo Giliberti, Vittoria Lobalsamo, Giuliana Metrangolo, Marica Noviello, Alessandra Vigna, Maurizio Zarcone, Francesco Di Gennaro, Vincenzo Ostilio Palmieri, Annalisa Saracino   +13 more
wiley   +1 more source

Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort

, 2019
International audienceTo analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), with a focus on neuropsychiatric adverse events (NPAEs)
Hue, H, Breaud, S, Miailhes, P, Nguyen, D, Montes, B, Meybeck, A, Perré, P, Laurichesse, H.,, Lanternier, F., Najioullah, F, Toméi, C, Miailhes, P., Hall, N, Santos, G Dos, Duvivier, C., May, T., Cua, E, Valette, M., Danion, F, Hustache-Mathieu, L, Berger, J., Robineau, O, Rey, David, Cavellec, M, Rouzaud, C, Chidiac, C., Chansombat, M, Ferré, V, Charlier, C, Mrozek, N, Corbin, V., V., Makinson, A, Fourreau, F, Batard, M, Reliquet, V, Pradier, C, André, M., Roux, S., Ritleng, A, Naqvi, A, Carta-Padovani, M, Naqvi, A., Morgand, M, Schneider, L, Roux, Stéphane, Aumeran, C., Lerolle, N, Valantin, M, Tomei, C., Lanternier, F, Casanova, S., Touam, F, Hentzien, M., Delobel, P., Rouzioux, C, Orticoni, M, Le Moing, V, Jovelin, T., Launay, M., Point, P, Vittecoq, D, Ferrando, S, Bouchez, S, Joly, V, Ravaux, I, Blanc, C, Biron, C, Pradier, M, Dournon, N, Degroodt, S, Biron, F, Debard, A., Hentzien, M, Guimard, T, Dhiver, C, Charpentier, C., Delestan, M, Pallier, C., Peytavin, G, Boutoille, D., Etienne, N, Tubiana, R, HALL, N., Leautez, S, Breaud, S., Bernaud, C, Landman, R, Priester, M, Muret, P., Lamaury, I, Drobacheff-Thiébaut, C, Rio, V, Guery, R, Etienne, C, Chidiac, C, Pierre-François, S, Ravaux, I., Ducassou, M., Cottalorda, J., Durant, J., Goesch, J, Lafon-Desmurs, B, CORBIN, V., Poizot-Martin, I, Lepiller, Q., Chirouze, C., Joulie, A, Ouissa, R, Bollangier, O, Letertre, P, Poizot-Martin, I., Delpierre, C., Bani-Sadr, Firouzé, Cotte, L, Lesens, O, Boucher, A., Alcaraz, I, Muret, P, Hall, N.,, Mondain, V, Risso, K, Rahli, D, Seang, S, Meftah, N, Matheron, S, Cottalorda, J, Avettand Fenoel, V, Lebrun, D., Ducassou, M, Alvarez, M., Meftah, N., Lefebvre, M, Valour, F, Caby, F, Goujard, C, Pallier, C, Babre, O, Barrail-Tran, A, Danion, F., Rosenthal, E., Melliez, H, Césaire, R., Deradji, O, Obry-Roguet, V, Abel, S, Fischer, P, Billaud, E., Charlier, C., Belkhir, A., Lions, C, Cabié, André, Billaud, E, Huleux, T., Montes, B., Jovelin, T, Curlier, E, Césaire, R, Caby, F., Hoen, B, Courjon, J, Laurichesse, H, Partisani, M, Mokhtari, M Saadia, Piffaut, M, Kmiec, I, Rodallec, A, Reynes, Jacques, Meddeb, L, Herrmann-Storck, C, Moing, V Le, Pasquier, J., Meddeb, L., Baud, O., Illiaquer, M, Launay, M, Baud, O, Sécher, S, Morineau, P, Reliquet, V., Oran, N, Flandre, P, Raffi, F., Frésard, A., Aubry, O, Cuzin, Lise, Galinier, A., Descamps, D., Pasquier, J, Godard, C, Julia, Z, Gagneux-Brunon, A, Pilmis, B., Parize, P, Brunet-Cartier, C, May, T, Cheret, A, Lesens, O., Henry, B, Katlama, Christine, Aumeran, C, Pilmis, B, Luquet-Besson, I, Hoen, B., Debard, A, Fuzibet, J, Raffi, F, Pircher, M., Pircher, M, Gervais, A, Belkhir, A, Ménard, A, Lepiller, Q, Casanova, S, Wehrlen-Pugliese, S, Valour, F., Lerolle, N., Valette, M, Schepers, K, Vittecoq, D., Allavena, Clotilde, Soria, A, Dupont, H Tissot, Pasquet, A., Oran, N., Yazdanpanah, Y., Zaegel-Faucher, O., Gilquin, J, Biron, F., Monclar, M, Matheron, S., Flandre, P., Berger, J, Ivanova, A., Monte, a De, Guen, L Le, Ouka, M, Brodard, V, Boyer, L, Bregigeon, Sylvie, Baclet, V, Morrier, M, Delobel, P, Rozé, B, Dellamonica, P., Bouiller, K., Viget, N, Duvivier, C, Ferry, Tristan, LAURICHESSE, H., Lortholary, O, Durant, J, Louni, F, Zouzou, G, Botelho-Nevers, E., Consigny, P, Boucher, A, Cotte, L., Point, P., Lambert, D, Hocqueloux, L, Lariven, S, Boyer, L., Jacomet, C, Makinson, A., Lions, C., Parize, P., Lelièvre, L, Peytavin, G., Boutoille, D, Rioux, C, Cheneau, C, Ceppi, C, Lelievre, L., Pillet, S, Lebrun, D, Martin-Blondel, G, Charpentier, C, Huleux, T, Bertone, H, Soria, A., Metsu, D, Lambert, D., Perpoint, T, Pillet, S., Ader, F., Dhiver, C., André, M, Khatchatourian, L, Biezunski, N, Choisy, P, Bernard-Henry, C, Rouzioux, C., Bouiller, K, Amazzough, K., Soavi, M, Delpierre, C, Hall, N., M.J., Bouillon, M, Botelho-Nevers, E, Lansalot, P, Blanco-Betancourt, C, Rodallec, A., Yazdanpanah, Y, Cessot, G, Martin-Blondel, Guillaume, Galinier, A, Chirouze, C, Porte, L., Benabdelmoumen, G, Gagneux-Brunon, A., Galie, S, Grossi, O, Corbin, V.,, Perpoint, T., Teicher, E., Delobel, Pierre, Laurichesse, H., H., Corbin, V, Louisin, C, Boibieux, A, Prouvost-Keller, B, Rioux, C., Lescure, F., Ressiot, E, Lucht, F., Rosenthal, E, Foltzer, A, Pugliese, Pascal, Cheneau, C., Aubry, O., Sausse, S, Mackoumbou-Nkouka, C, Ivanova, A, Vidal, M, Dellamonica, P, Brochier, C, Zaegel-Faucher, O, Porte, L, Atoui, N, Fagour, L, N’guyen, Y, Bossi, P, Fabre, I, Perbost, I, Ajana, F, Boibieux, A., Quertainmont, Y, Lescure, F, Obry-Roguet, V., Pasquet, A, Ferre, V., Morgand, M., Mondain, V., de Mautort, E, André-Garnier, E, Guery, R., Partisani, M., Alvarez, M, Descamps, D, Frésard, A, Lourenco, Jeremy, Bozon, F, Joulié, A., Najioullah, F., Bonnet, B, Lucht, F, André-Garnier, E., Demonchy, E, Agher, R, Merrien, D, Garraffo, R, Amazzough, K, Montoya Ferrer, A., Lafon-Desmurs, B., Palich, R, Ferrer, a Montoya, de Boever, C Merle, Perré, P., Saune, K, Abel, S., Lortholary, O., Ader, F, Teicher, E   +382 more
core   +1 more source