Results 61 to 70 of about 2,862,567 (165)
Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies
Medicinal Research Reviews, EarlyView.ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva +23 more
wiley +1 more source
The end of the line? A case of drug resistance to third-line antiretroviral therapy
Southern African Journal of HIV Medicine, 2016 HIV drug resistance has been described in all antiretroviral drug classes and threatens the long-term success of HIV treatment. Here, we describe the first reported case of acquired resistance to the integrase strand transfer inhibitors in South Africa ...
Theresa M. Rossouw +2 more
doaj +1 more source
Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi
Yeast, EarlyView.Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng +4 more
wiley +1 more source
AIDS Research and Therapy, 2020 Background In resource-limited settings, multi-experienced HIV infected patients are often prescribed raltegravir for salvage therapy. Patients failing raltegravir-containing regimens require other drugs including other integrase inhibitors.
Aurelio Orta-Resendiz +4 more
doaj +1 more source
Cell Proliferation, EarlyView.In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu +6 more
wiley +1 more source
HIV Medicine, EarlyView.Abstract Objectives Dyslipidaemia is highly prevalent among people living with human immunodeficiency virus (HIV) and contributes to increased cardiovascular risk. Although lifestyle interventions are recommended, evidence specific to people living with HIV remains limited. Previous reviews have primarily focused on dietary interventions or low‐density
Maki Aomori, Hitomi Maeda
wiley +1 more source
Development of an HIV-1 integrase enzyme strand transfer assay [PDF]
, 2011 The Human Immunodeficiency Virus type 1 (HIV-1) integrase is an essential enzyme required for viral replication. Integrase forms part of an ensemble of proteins known as the preintegration complex and functions by a two-step process.
Qasim, Muhammad
core
, 2016 The crystal structure of Tn5 transposase−DNA complex was used in docking experiments to predict binding modes of HIV-1 integrase strand transfer inhibitors (INSTIs).
Alba Chimirri (76729) +3 more
core +1 more source
HIV Medicine, EarlyView.Abstract Background Prior to the COVID‐19 pandemic, antiretroviral therapy (ART) coverage and viral suppression were improving across Europe; however, the impact of the pandemic on HIV care remains uncertain. Methods In‐person visits, ART coverage and viral suppression among those on ART were described in the EuroSIDA cohort for each calendar year from
Olga Fursa +18 more
wiley +1 more source
, 2015 The search for new molecular constructs that resemble the critical two-metal binding pharmacophore required for HIV integrase strand transfer inhibition represents a vibrant area of research within drug discovery.
Pravien Abeywickrema (1503235) +27 more
core +1 more source