Results 51 to 60 of about 2,862,567 (165)

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

Durability of first-line regimens including integrase strand transfer inhibitors (INSTIs): data from a real-life setting

, 2019
To evaluate the durability of three integrase strand transfer inhibitors (INSTIs) and two NRTIs in ART-naive ...
Lo Caputo, Sergio, Cingolani A, Caramello P, Segala D, Cecchetto M, Nunnari G, Angarano G, Bandera A, Quiros Roldan E, Sangiovanni V, Quartu S, Minardi C, Girardi E, Starnini G, Maggiolo F, Cacopardo B, Di Martino F, Cattelan AM, Cascio A, Fontana Del Vecchio R, Costantini, Andrea, Marinello S, Andreoni M, Di Perri G, Chiodera A, Madeddu G, Baldelli F, Barocci V, von Schloesser F, Sarmati L, Gentile I, Tavelli A, Suardi C, Celesia B, Maddaloni L, Ialungo A., Bassetti M, Pellicanò G, Cristaudo A, Rossotti R, Londero A, Mazzotta, Valentina, Carletti F, Di Caro A, Ursitti MA, Plazzi MM, Acinapura R, Lazzarin A, Saracino A, Antinori, Andrea, Capetti A, Antinori A, Nozza S, Di Biagio, Antonio, Tincati C, Cozzi-Lepri A, Viale P, Iaiani G, Pellizzer G, Castagna A, Sighinolfi L, Falasca K, Bai F, d'Arminio Monforte, Antonella, Bagella P, Di Biagio A, Ippolito G, Blanc P, Cicalini S, Fanti I, Rodanò' A, Lo Caputo S, Monno L, Bobbio N, Fabrizio C, Molteni C, Capozzi M, Bonora S, Puzzolante C, Di Giuli C, Giacometti A, Menzaghi B, Mazzarello G, Truffa S, Magnani G, Marchetti GC, Moioli MC, Orofino GC, Gianotti N, Cinque P, Iardino R, Parruti G, Rusconi S, Milini P, Savinelli S, Sciandra M, Rivano Capparucia M, Galli M, De Luca A, Rezza G, Galli L, Cassola G, Gagliardini R, Verucchi G, Colomba C, Castelnuovo F, Rizzardini G, Puoti M, Gianotti, Nicola, Prota G, Vergori A, Marchetti, Giulia, Guaraldi G, Mondi A, Castelli F, Lorenzotti S, Perno CF, Francisci D, Borderi M, Santoro MM, Sozio F, Costantini A, Cauda R, Vullo V, Pinnetti C, Cozzi-Lepri, Alessandro, Capobianchi MR, Esposito V, Graziano S, Ceccherini-Silberstein F, Marchetti G, Pan A, Castagna, Antonella, Viscoli C, Macchia M, Carrara S, Viviani F, Abeli C, Bonfanti P, Lorenzini P, Gori A, Alessandrini A, Rusconi, Stefano, Ridolfo AL, Baldin G, Latini A, Borgia G, Schiaroli E, d'Arminio Monforte A, Salpietro S, Pozzetto I, Mazzarello, Giovanni, Donati V, Calcagno A, Lapadula G, Vecchiet J, Balotta C, Piolini R, Migliorino C, Mussini C, Rossetti B, Manfrin V, Lichtner M, Petrone F, Franco A, Vichi F   +165 more
core   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Rapid onset and offset of the interaction between rifampicin and long‐acting cabotegravir/rilpivirine: A pharmacokinetic case report

British Journal of Clinical Pharmacology, EarlyView.
Long‐acting intramuscular cabotegravir/rilpivirine (LA CAB/RPV) is contraindicated with rifampicin because of the risk of markedly reduced antiretroviral exposure, although clinical pharmacokinetic data for this interaction are lacking. We describe a 49‐year‐old man with virologically suppressed HIV‐1 infection receiving LA CAB/RPV every 8 weeks who ...
Emilie M. Gieling, Lisanne A. H. Bevers, Wouter L. Smit, Rosa H. Elias, Annelies Verbon, David M. Burger, Berend J. van Welzen   +6 more
wiley   +1 more source

Homogeneous high-throughput screening assays for HIV-1 integrase 3beta-processing and strand transfer activities.

, 2005
HIV-1 integrase (HIV-IN) is a well-validated antiviral drug target catalyzing a multistep reaction to incorporate the HIV-1 provirus into the genome of the host cell.
Wolff, Karen, Brinker, Achim, Gunderson, Drew, Caldwell, Jeremy, Scott Lesley, Drew Gunderson, Karen Wolff, Heath Klock, Kirk Niswonger, Yu Wang, Jeremy Caldwell, Yin, Hong, Wang, Yu, Hong Yin, Klock, Heath, Lesley, Scott, Achim Brinker, Kimberly Bieza, Matzen, Jason, Hale, Joanna, Jason Matzen, Kelli Kuhen, Kuhen, Kelli, Bieza, Kimberly, Joanna Hale, Niswonger, Kirk   +25 more
core   +1 more source

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors [PDF]

, 2017
Integrase mutations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer inhibitors (INSTIs), raltegravir (RAL) and elvitegravir (EVG).
Cherepanov, Peter, Maskell, Daniel, Métifiot, Mathieu, Mathieu Métifiot, Terrence R. Burke, Marchand, C, Smith, SJ, Daniel P. Maskell, Valerie E. Pye, Hughes, SH, Pommier, Yves, Zhao, XZ, Hughes, Stephen,, Yves Pommier, Burke, TR, Christophe Marchand, Cherepanov, P, Pye, VE, Steven J. Smith, Burke, Terrence, Pye, Valerie,, Katherine Fesen, Marchand, Christophe, Xue Zhi Zhao, Smith, Steven,, Peter Cherepanov, Stephen H. Hughes, Maskell, DP, Pommier, Y, Fesen, K, Zhao, Xue Zhi, Fesen, Katherine, Metifiot, M   +32 more
core   +1 more source

Brief Histories of Retroviral Integration Research and Associated International Conferences

Viruses
The field of retroviral integration research has a long history that started with the provirus hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase enzymes.
Duane P. Grandgenett, Alan N. Engelman
doaj   +1 more source

Weight gain on dolutegravir: Association is not the same as causation

Southern African Journal of HIV Medicine, 2023
No abstract available.
Gary Maartens, Phumla Sinxadi, W.D. Francois Venter   +2 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Non–AIDS‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

International Journal of Cancer, EarlyView.
ABSTRACT People with HIV (PWH) are living longer, but contemporary data on non–AIDS‐defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow‐up was grouped into 2000–2007, 2008–2015, and 2016–2023. Incidence rates (IRs) were calculated
Giacomo Pozza, Maddalena Matone, Letizia Oreni, Giorgia Carrozzo, Beatrice Caloni, Maria Vittoria Cossu, Davide Moschese, Anna Lisa Ridolfo, Cristina Gervasoni, Cinzia Fasola, Nicla La Verde, Davide Dalu, Spinello Antinori, Andrea Gori, Andrea Giacomelli   +14 more
wiley   +1 more source