Results 41 to 50 of about 2,862,567 (165)

Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-brain barrier integrity and function

Frontiers in Pharmacology, 2023
The implementation of combined antiretroviral therapy (cART) significantly reduces the mortality associated with human immunodeficiency virus (HIV) infection.
Chang Huang, Tozammel Hoque, Reina Bendayan   +2 more
doaj   +1 more source

Prevalence of resistance to integrase strand-transfer inhibitors (INSTIs) among untreated HIV-1 infected patients in Morocco

BMC Research Notes, 2018
Objective The integrase strand-transfer inhibitors (INSTIs) are an important class in the arsenal of antiretroviral drugs designed to block the integration of HIV-1 cDNA into the host DNA through the inhibition of DNA strand transfer.
Najwa Alaoui, Moulay Abdelaziz El Alaoui, Nadia Touil, Hicham El Annaz, Marouane Melloul, Reda Tagajdid, Naoufal Hjira, Mohamed Boui, El Mostapha El Fahime, Saad Mrani   +9 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Integrase Strand Transfer Inhibitors and Weight Gain in Children and Youth with Perinatal Human Immunodeficiency Virus in the DC Cohort

, 2021
We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0-19 years) in the United States and report an increased rate of change of BMI-for-age z score after initiating integrase strand transfer inhibitors ...
Rakhmanina, Natella, Reamer, Susan, Rakhmanina, Natella Y., Bezabeh, Tsedenia, Castel, Amanda D., Sapozhnikova, Alla, Kulie, Paige, Koay, Wei Li A., Levy, Matthew E., Temprosa, Marinella, Kharfen, Michael, Monroe, Anne, Bamdad, Aria, Ma, Yan, Greenberg, Alan, Serlin, Michael, Burrows, Pamela Katzen, Happ, Lindsey Powers, Younes, Naji, Wilcox, Ronald, Akselrod, Hana, Wilbourn, Brittany, Kumar, Princy, Jaurretche, Maria, Levy, Matthew, D\u27Angelo, Lawrence, Castel, Amanda, Rana, Sohail, Byrne, Morgan, Peterson, James, Dirajlal-Fargo, Sahera   +30 more
core   +1 more source

Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors

Molecules, 2011
Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). In recent years our research group has been engaged in the stucture-function study of this enzyme and in the development
Alba Chimirri, Caterina Elisa Faliti, Zeger Debyzer, Rosaria Gitto, Laura De Luca, Sara De Grazia, Stefania Ferro   +6 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases [PDF]

, 2016
HIV integrase (IN) strand transfer inhibitors (INSTIs) are among the newest anti-AIDS drugs; however, mutant forms of IN can confer resistance. We developed noncytotoxic naphthyridine-containing INSTIs that retain low nanomolar IC50 values against HIV-1 ...
Christophe Marchand (43010), Burke, TR, Katherine Fesen (1397647), Cherepanov, P, Stephen H. Hughes (1397653), Xue Zhi Zhao (1397659), Yves Pommier (11158), Terrence R. Burke (1397665), Marchand, C, Pye, VE, Smith, SJ, Daniel P. Maskell (1397650), Steven J. Smith (1397668), Mathieu Metifiot (1397662), Peter Cherepanov (369), Hughes, SH, Maskell, DP, Pommier, Y, Zhao, XZ, Fesen, K, Valerie E. Pye (1397656), Metifiot, M   +21 more
core   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Cabotegravir, the Long-Acting Integrase Strand Transfer Inhibitor, Potently Inhibits Human T-Cell Lymphotropic Virus Type 1 Transmission in vitro

Frontiers in Medicine, 2022
Human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus most prevalent in southwestern Japan, sub-Saharan Africa, Australia, South America, and the Caribbean. Latest figures approximate 10 million people worldwide to be infected with HTLV-1.
Bethany S. Schneiderman, Michal S. Barski, Goedele N. Maertens   +2 more
doaj   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source