Results 141 to 150 of about 10,473 (233)

Screening for bone health in older people with HIV: Uptake and outcomes from a large UK outpatient HIV service

HIV Medicine, Volume 27, Issue 9, Page 1460-1467, September 2026.
Abstract Objectives Bone health is negatively affected in people with HIV, and the risks of osteoporosis and fragility fractures are increased. The objective of this study was to describe the characteristics of those accessing bone health screening and identify factors associated with osteoporosis.
Rhys Nicholas, Kate Alford, Colin Fitzpatrick, Jaime Vera   +3 more
wiley   +1 more source

Dolutegravir population pharmacokinetics in racially, sex‐ and age‐diverse and antiretroviral therapy‐experienced adults with HIV in the United States

HIV Medicine, Volume 27, Issue 9, Page 1517-1529, September 2026.
Abstract Objectives Dolutegravir (DTG) has been associated with weight gain in women with HIV, Black people with HIV and people with HIV60 years. This study aimed to characterise DTG population pharmacokinetics (PopPK) in a diverse population including these sub‐populations.
Adrian Khoei, Andrew Edmonds, Yen Chang, Catalina Ramirez, Mackenzie Vogan, Amanda Poliseno, Steven Wolinsky, Ken Ho, Todd T. Brown, Joseph B. Margolick, Jacquett Batson, Jennifer Hoffmann, Mark A. Marzinke, Mirjam‐Colette Kempf, Maria L. Alcaide, Joffi Effoe, Cecile D. Lahiri, Igho Ofotokun, Anandi N. Sheth, Stephen Gange, Audrey L. French, Bani Tamraz, Bradley E. Aouizerat, Phyllis C. Tien, Seble G. Kassaye, Jack DeHovitz, Kathryn Anastos, Kara W. Chew, Michelle Floris‐Moore, Julie B. Dumond   +29 more
wiley   +1 more source

Long‐Acting Cabotegravir/Rilpivirine Reduces Immune‐Activation and ‐Senescence in People With HIV With CMV Co‐Infection

Immunology, Volume 179, Issue 1, Page 138-148, September 2026.
This study investigates the impact of switching to long‐acting (LA) injectable cabotegravir and rilpivirine (CAB/RPV‐LA) on immune‐activation and ‐senescence in people with HIV (PWH). Thirty‐seven PWH switching to CAB/RPV‐LA and nine continuing oral ART were analysed over 72 weeks. LA therapy led to significant reductions in activation T and senescence
Mariasilvia Guardiani, Eeva Tortellini, Anna Carraro, Maria Antonella Zingaropoli, Lorenzo Ansaldo, Alessandra Grimaldi, Serena Vita, Federica Dominelli, Fabio Mengoni, Caterina Pasquazzi, Ombretta Turriziani, Maria Rosa Ciardi, Vincenzo Vullo, Claudio Maria Mastroianni, Raffaella Marocco, Cosmo Del Borgo, Miriam Lichtner   +16 more
wiley   +1 more source

DJ: Tdd-4, a DNA transposon of Dictyostelium that encodes proteins similar to LTR retroelement integrases

, 1999
Tdd-4 is the first DNA transposon to be isolated from Dictyostelium discoideum. This element was isolated by insertion into a target plasmid. Two classes of elements were identified which include a 3.8 kb version and a 3.4 kb deleted version.
David J. Wells
core  

In vitro properties of large serine integrase hybrids derived from ϕC31 and TG1 integrases. [PDF]

Nucleic Acids Res
Lawson-Williams M, Holland A, Bello AJ, Rice PA, Olorunniji FJ.   +4 more
europepmc   +1 more source

Sex differences in insulin resistance and associated metabolic and inflammatory markers among adults with and without HIV in Zambia

Physiological Reports, Volume 14, Issue 17, September 2026.
Abstract Insulin resistance (IR) contributes substantially to cardiovascular disease and type 2 diabetes mellitus, with increasing concern among people living with HIV (PLWH). However, sex‐specific factors of IR in sub‐Saharan Africa remain poorly understood.
Frederick Sibbenga, David Chisompola, Mumbo Chipuma, Martin Chakulya, Propheria Lwiindi, Masiliso A. Liamba, Benson M. Hamooya, Joreen P. Povia, Situmbeko Liweleya, Sepiso K. Masenga   +9 more
wiley   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Comprehensive profiling of insertion sequences and eukaryotic-like transposons across archaeal genomes. [PDF]

BMC Genomics
Peng XY, Gong ZC, Mao SQ.
europepmc   +1 more source

Glomhopper-a subfamily of DUF3504-encoding CryptonA elements in Glomeromycota. [PDF]

Mob DNA
Krysińska M, Barua D, Muszewska A.
europepmc   +1 more source

A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases.

, 1991
We have isolated a rat cDNA, named FE65, hybridizing to an mRNA of about 2,300 nucleotides present in rat brain, undetectable in rat liver and very poorly represented in other tissues.
Cimino F, DUILIO, ANGELA, AMMENDOLA, ROSARIO, ZAMBRANO, NICOLA, Mogavero AR, RUSSO, TOMMASO   +5 more
core