Results 181 to 190 of about 10,041 (223)
Structural basis of unidirectional DNA recombination by the ϕC31 serine integrase
Sun YE +5 more
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New Applications for Phage Integrases [PDF]
Journal of Molecular Biology, 2014 Within the last 25 years, bacteriophage integrases have rapidly risen to prominence as genetic tools for a wide range of applications from basic cloning to genome engineering. Serine integrases such as that from ϕC31 and its relatives have found an especially wide range of applications within diverse micro-organisms right through to multi-cellular ...
Paul C M Fogg +2 more
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Applications of Serine Integrases in Synthetic Biology over the Past Decade
SynBio, 2023 Serine integrases are emerging as one of the most powerful biological tools for biotechnology. Over the past decade, many research papers have been published on the use of serine integrases in synthetic biology.
Fang Ba, Wan-Qiu Liu, Jian Li
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Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae [PDF]
BMC Biotechnology, 2016 Background: Phage-encoded serine integrases, such as ϕC31 integrase, are widely used for genome engineering but have not been optimized for use in Saccharomyces cerevisiae although this organism is a widely used organism in biotechnology. Results: The
William R A Brown, Brown William R A
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Making serine integrases work for us [PDF]
Current Opinion in Microbiology, 2017 DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
W Marshall Stark
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Oligomerization of Retrovirus Integrases
2018Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric 'intasome' complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of ...
Duane P, Grandgenett, Hideki, Aihara
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Structure and function of retroviral integrase
Nature Reviews Microbiology, 2021A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhibitors are widely used to treat people living with HIV ...
Goedele N. Maertens +2 more
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Serine Integrases: Advancing Synthetic Biology [PDF]
ACS Synthetic Biology, 2018 Serine integrases catalyze precise rearrangement of DNA through site-specific recombination of small sequences of DNA called attachment (att) sites. Unlike other site-specific recombinases, the recombination reaction driven by serine integrases is highly
Christine A Merrick, Susan J Rosser
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1995
Abstract The linear DNA copy of the HIV genome made by reverse transcription must be integrated into a chromosome of the infected cell in order to be stably maintained and efficiently transcribed. DNA integration is therefore a necessary step in the viral replication cycle. HIV DNA is inserted into the host genome by a specialized DNA
R Craigie, A B Hickman, A Engelman
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Abstract The linear DNA copy of the HIV genome made by reverse transcription must be integrated into a chromosome of the infected cell in order to be stably maintained and efficiently transcribed. DNA integration is therefore a necessary step in the viral replication cycle. HIV DNA is inserted into the host genome by a specialized DNA
R Craigie, A B Hickman, A Engelman
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The clinical pharmacology of integrase inhibitors
Expert Review of Clinical Pharmacology, 2018Introduction: Treatment of HIV infection has consistently evolved in the last three decades. A steady improvement in efficacy tolerability, safety, and practical aspects of treatment intake has made HIV infection much easier to manage over the long term, and in optimal treatment conditions the life expectancy of persons living with HIV infection now ...
Giovanni, Di Perri +3 more
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