Results 191 to 200 of about 10,041 (223)
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Zinc binding by retroviral integrase
Biochemical and Biophysical Research Communications, 1992Zinc binding by integrase from Moloney murine leukaemia virus and a protein A fusion protein containing integrase from human immunodeficiency virus type 1 was demonstrated by a zinc blotting technique using 65ZnCl2. Autoradiography revealed a clear band that was absent from the appropriate controls.
A R, McEuen +7 more
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Expert Opinion on Therapeutic Targets, 2001
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
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Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is an attractive target for the development of new therapeutics.
Khampoune, Sayasith +2 more
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Substrate Recognition by Retroviral Integrases
1999Substrate recognition by the retroviral IN enzyme is critical for retroviral integration. To catalyze this recombination event, IN must recognize and act on two types of substrates, viral DNA and host DNA, yet the necessary interactions exhibit markedly different degrees of specificity.
M, Katzman, R A, Katz
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Resistance to HIV integrase inhibitors
Current Opinion in HIV and AIDS, 2012HIV integrase inhibitors are potent antiretroviral drugs that efficiently decrease viral load in patients. Emergence of resistance mutations against this new class of drugs represents a threat to their long-term efficacy. The purpose of this review is to provide new information about the most recent mutations identified and other mutations that confer ...
Thibault, Mesplède +2 more
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The Cis-Trans Paradox of Integrase
Science, 1997During recombination, strands of DNA break and are rejoined, producing the reshuffling of genetic information that underlies genetic diversity. Jayaram discusses the chemical mechanism underlying this process, including the controversial cis-trans paradox, as revealed by the x-ray crystallographic structure of the recombinase lambda ...
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HIV Integrase Structure and Function
1999HIV integrase consists of three domains, the structures of which have been individually determined by X-ray crystallography or NMR spectroscopy. The core domain, spanning residues 50-212, is responsible for the catalytic activity of the enzyme.
D, Esposito, R, Craigie
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High fidelity one‐pot DNA assembly using orthogonal serine integrases
Biotechnology Journal, 2023Sean D Colloms +2 more
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