Results 211 to 220 of about 7,664,175 (345)

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Transcatheter tricuspid edge-to-edge repair in frail older adults: a cardiogeriatric framework for integrated care. [PDF]

Aging Clin Exp Res
Esser R, Harboun M, Esteban M, Larbaneix M, Farges C, Akuda G, Hamdi A, Mondragon A, Durgeat SN, Maurou O, Palermo V.   +10 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Moving forward, leaving the patients behind? A multilevel assessment framework for evaluating patient-centred, integrated care quality. [PDF]

Qual Life Res
Cassidy S, Lintvedt O, Odeh F, Granja C, Solvoll T.   +4 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Voluntary & Community Organisations: Not the Third but the First Sector of Integrated Care? [PDF]

Int J Integr Care
Miller R, Nelson M, Fullerton I, Gradinger F, Rees J, Saragosa M.   +5 more
europepmc   +1 more source

Palliative Care in the Community: A Systematic Review of Integrated Services Combining Radiation Therapy for Pain Relief, Home-Based Nursing, and Family Physician Support

Eman Abdullah Alaradi, Zainab Abdullah Al Aradi, Huda Mutir Alatawi, Shrouq Awad Alatawi, Ali Saleh Alessi, Samar Yahya Dilyh, Zahra Makki Jaffar Al-Eid, Ali Muhammad Alqubbi, Nuha Yahya Dilyh, Zahra Abdulkarim Al Mohmed   +9 more
openalex   +2 more sources

AI Integrated Entertaining and Monitoring System for Daily Care of Elders [PDF]

A.K.M Sazzadur Rahman, Mahedi Kamal, Afrina Kabir Zinia, Amrin Akhter Pinky, Sabrina Afrin Toma, Ali Khan, Muhammad Akhtaruzzaman, Nafiz Imtiaz Khan, Muhammad Nazrul Islam   +8 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source