Results 101 to 110 of about 554,536 (332)

Integrated care pathways: a new approach for integrated care systems

British Journal of General Practice, 2023
Christina van der Feltz-Cornelis, Emily Attree, Mel Heightman, Mark Gabbay, Gail Allsopp   +4 more
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Integrated care pathways in neurosurgery: A systematic review

, 2021
Keng Siang Lee, Stefan Yordanov, Daniel J. Stubbs, Ellie Edlmann, Alexis Joannides, Benjamin M. Davies   +5 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Building Bricks of Integrated Care Pathway for Autism Spectrum Disorder: A Systematic Review. [PDF]

Int J Mol Sci, 2023
Fulceri F, Gila L, Caruso A, Micai M, Romano G, Scattoni ML.   +5 more
europepmc   +1 more source

The impact of including a medication review in an integrated care pathway: A pilot study [PDF]

, 2022
Anaïs Payen, Claire Godard‐Sebillotte, Nadia Sourial, Julien Soula, David Verloop, M.-M. Defebvre, Corinne Dupont, Delphine Dambre, Antoine Lamer, Jean‐Baptiste Beuscart   +9 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Global voices on atrial fibrillation care in China

Heart Rhythm O2
An aging population, coupled with the high prevalence of physical inactivity, obesity, dyslipidemia, hypertension, and diabetes mellitus, has led to a significant increase in the incidence and prevalence of atrial fibrillation (AF) in China.
Mingfang Li, MD, PhD, Minglong Chen, MD, Yutao Guo, MD, Gregory Y.H. Lip, MD   +3 more
doaj   +1 more source

Multidisciplinary integrated care pathway for von Hippel-Lindau disease. [PDF]

Cancer, 2022
Wolters WPG, Dreijerink KMA, Giles RH, van der Horst-Schrivers ANA, van Nesselrooij B, Zandee WT, Timmers HJLM, Seute T, de Herder WW, Verrijn Stuart AA, Kilic E, Brinkman WM, Zondervan PJ, Vandertop WP, Daniels AB, Wolbers T, Links TP, van Leeuwaarde RS.   +17 more
europepmc   +1 more source