Results 61 to 70 of about 520,784 (306)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Statistical Timing Analysis for Subthreshold Circuit Based on Bayesian Inference

IEEE Access
Accurately predicting the delay distribution of subthreshold circuits is crucial for verifying the timing closure of digital circuits and estimating parameter yields.
Donglin Liu, Yuping Wu, Zhiqiang Li, Xuelian Zhang, Xi Tian   +4 more
doaj   +1 more source

Phased Array Systems in Silicon [PDF]

, 2004
Phased array systems, a special case of MIMO systems, take advantage of spatial directivity and array gain to increase spectral efficiency. Implementing a phased array system at high frequency in a commercial silicon process technology presents several ...
Chunara, R., Guan, X., Hajimiri, A., Hashemi, H., Komijani, A., Natarjan, A.   +5 more
core  

Practical formulation of the relation between filter specifications and the requirements for integrator circuits [PDF]

, 1989
The design of integrated, high-frequency, continuous-time filters has made considerable progress in the past few years. As the signal frequencies increase the design of the integrator circuits used in most of these filters becomes more critical.
Heij, W.J.A. de, Hoen, K., Seevinck, E.
core   +2 more sources

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Reverse dark current in organic photodetectors and the major role of traps as source of noise

Nature Communications, 2021
The suppression of dark current in organic photodetectors (OPDs) is important for maximizing the performance of the devices. Here, the authors report the relationship between the high dark saturation current and the presence of mid-gap trap states in ...
Jonas Kublitski, Andreas Hofacker, Bahman K. Boroujeni, Johannes Benduhn, Vasileios C. Nikolis, Christina Kaiser, Donato Spoltore, Hans Kleemann, Axel Fischer, Frank Ellinger, Koen Vandewal, Karl Leo   +11 more
doaj   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

3D package thermal analysis and thermal optimization

Case Studies in Thermal Engineering
3D packaging mainly uses TSVs (Through Silicon via) to vertically interconnect multiple chips, achieving the purpose of signal transmission and electrical connection. As a popular advanced packaging method, its research is of great significance. Although
Yaohui Deng, Peisheng Liu, Zhao Zhang, Jiajie Jin, Pengpeng Xu, Lei Yan   +5 more
doaj   +1 more source

A low‐voltage and low‐power current‐mode winner‐take‐all (maximum) circuit

Electronics Letters, 2023
In this Letter, a new low‐voltage and low‐power current‐mode winner‐take‐all (WTA) circuit is proposed. The proposed circuit is able to operate with a low supply voltage requirement while exhibiting a high accuracy.
Hossein Yaghoobzadeh Shadmehri, Mehdi Saberi, Ehsan Rahiminejad, Mohammad Tavakkoli Ghouchani   +3 more
doaj   +1 more source