Results 81 to 90 of about 274,368 (254)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Prediction and prevention of the next pandemic zoonosis. [PDF]

, 2012
Most pandemics--eg, HIV/AIDS, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes.
Carroll, Dennis, Daszak, Peter, Karesh, William B, Lipkin, W Ian, Mazet, Jonna AK, Morse, Stephen S, Parrish, Colin R, Woolhouse, Mark, Zambrana-Torrelio, Carlos   +8 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Stronger Partnerships for Safer Food: An Agenda for Strengthening State and Local Roles in the Nation's Food Safety System [PDF]

, 2009
Examines federal, state, and local agencies' responsibilities, strengths, and weaknesses in ensuring food safety. Recommends systemwide reforms to enhance state and local roles and improve surveillance, outbreak response, and regulation and ...
Michael R. Taylor, Stephanie D. David
core  

Surveillance and response systems for elimination of tropical diseases : summary of a thematic series in infectious diseases of poverty [PDF]

, 2016
The peer-reviewed journal Infectious Diseases of Poverty provides a new platform to engage with, and disseminate in an open-access format, science outside traditional disciplinary boundaries.
Bergquist, Robert, Tanner, Marcel, Utzinger, Jürg, Yap, Peiling, Zhou, Xia, Zhou, Xiao-Nong   +5 more
core   +3 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Big Data Analytics for Integrated Infectious Disease Surveillance in sub-Saharan Africa

South African Journal of Information Management
Background: Infectious disease outbreaks are common in sub-Saharan Africa (SSA). Consequently, integrated public health surveillance has become increasingly essential for the region.
Mourine S. Achieng, Oluwamayowa O. Ogundaini   +1 more
doaj   +1 more source

Study of Utilization of Integrated Disease Surveillance and Response Data in Controlling Infectious Diseases among Public Health Facilities in Kiambu County, Kenya

International Journal of Advances in Scientific Research and Engineering, 2021
Integrated Disease Surveillance and Response entails data collection, analysis, interpretation, and feedback on communicable and non-communicable diseases. It enables health workers to detect and respond to these diseases.
Ferdinand Wabwile Milliano, E. Kabiru, Dr.George O. Otieno   +2 more
semanticscholar   +1 more source

Gap Analysis of Environmental Health Research in Malawi : Report to the National Commission of Science and Technology [PDF]

, 2010
The aim of this consultancy was to assess the current gaps in research for the environmental health sector in Malawi, and to recommend research priorities and an effective action plan to address these ...
Lungu, Kingsley, Morse, Tracy, Taulo, Steven   +2 more
core