Results 111 to 120 of about 298,958 (272)
Perturbation-theory informed integrators for cosmological simulations
Journal of Computational PhysicsLarge-scale cosmological simulations are an indispensable tool for modern cosmology. To enable model-space exploration, fast and accurate predictions are critical. In this paper, we show that the performance of such simulations can be further improved with time-stepping schemes that use input from cosmological perturbation theory.
Florian List, Oliver Hahn 0002
openaire +4 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
CríticaIn this article, I evaluate which version of panpsychism is best suited to address the challenges faced by a theory of consciousness. I first argue that a panpsychist theory is more likely to be successful if it meets two conditions: (1) it must be ...
Sergio Cermeño Aínsa
doaj +1 more source
Separating weak integrated information theory into inspired and aspirational approaches. [PDF]
Neurosci Conscious, 2023 Leung A, Tsuchiya N.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Synchronization, Information, and Brain Dynamics in Consciousness Research
Applied SciencesUnderstanding consciousness requires bridging theoretical models and clinically measurable brain dynamics. This review integrates three complementary frameworks that converge on a dynamical view of conscious processing: continuous formulations of ...
Francisco J. Esteban +3 more
doaj +1 more source
Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms. [PDF]
PLoS Comput Biol, 2023 Albantakis L +15 more
europepmc +1 more source
Beauty and the Beast: The Theory and Practice of Information Integration [PDF]
, 2006 Information integration is becoming a critical problem for businesses and individuals alike. Data volumes are sky-rocketing, and new sources and types of information are proliferating. This paper briefly reviews some of the key research accomplishments in information integration (theory and systems), then describes the current state-of-the-art in ...
openaire +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source