Results 121 to 130 of about 23,332,431 (264)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Phi fluctuates with surprisal: An empirical pre-study for the synthesis of the free energy principle and integrated information theory. [PDF]

PLoS Comput Biol, 2023
Lundbak Olesen C, Waade PT, Albantakis L, Mathys C.   +3 more
europepmc   +1 more source

Integrated Information in Process-Algebraic Compositions

, 2019
Integrated Information Theory (IIT) is most typically applied to Boolean Nets, a state transition model in which system parts cooperate by sharing state variables.
Tommaso Bolognesi, Bolognesi T.
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

An adversarial collaboration protocol for testing contrasting predictions of global neuronal workspace and integrated information theory. [PDF]

PLoS One, 2023
Melloni L, Mudrik L, Pitts M, Bendtz K, Ferrante O, Gorska U, Hirschhorn R, Khalaf A, Kozma C, Lepauvre A, Liu L, Mazumder D, Richter D, Zhou H, Blumenfeld H, Boly M, Chalmers DJ, Devore S, Fallon F, de Lange FP, Jensen O, Kreiman G, Luo H, Panagiotaropoulos TI, Dehaene S, Koch C, Tononi G.   +26 more
europepmc   +1 more source

Information Theory and Computational Thermodynamics: Lessons for Biology from Physics

, 2012
We survey a few aspects of the thermodynamics of computation, connecting information, thermodynamics, computability and physics. We suggest some lines of research into how information theory and computational thermodynamics can help us arrive at a better
Hector Zenil
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The ambiguous feeling between "mine" and "not-mine" measured by integrated information theory during rubber hand illusion. [PDF]

Sci Rep, 2022
Niizato T, Nishiyama Y, Sakamoto K, Kazama T, Okabayashi T, Yamaguchi T.   +5 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Does integrated information theory make testable predictions about the role of silent neurons in consciousness? [PDF]

Neurosci Conscious, 2022
Bartlett G.
europepmc   +1 more source