Results 71 to 80 of about 15,696 (258)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
IEEE Photonics Journal, 2019 A novel method to determine the dispersion of the quadratic electro-optic effect in nonlinear optical materials by using a silicon-on-insulator microring resonator is presented.
Patrick Steglich +6 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Integrated Optics Some Aspects
, 2013 Status of some key individual integrated optics components, their application in the field of telecommunications, integrated optoelectronic circuits, fibre optics sensors, optical interconnects and logic devices are highlighted in this paper ...
Hradaynath, R.
core +1 more source
Optically controlled redshift switching effects in hybrid fishscale metamaterials
AIP Advances, 2018 We numerically demonstrate optically controlled THz response in a hybrid fishscale metamaterial with embedded photoconductive silicon at oblique incidence of TE wave. The oblique incidence allows excitation of Fano-type trapped mode resonance in a 2-fold
Yu Wang +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Integrated optics for astronomical interferometry
, 1999 We propose a new instrumental concept for long-baseline optical single-mode interferometry using integrated optics which were developed for telecommunication.
P. Kern +11 more
core +1 more source
Automated model for characterization of VCSEL circuit-level parameters using machine learning [PDF]
, 2023 We propose a machine learning-based model to extract physical parameters characterizing stationary and dynamic behavior of a VCSEL. The model is trained with circuit-level simulations of light-current and S21 characteristics.
Bardella, Paolo +7 more
core
Scientific Reports, 2017 Selective doping of Ni2+ in octahedral sites provided by nanocrystals embedded in glass-ceramics (GCs) is crucial to the enhancement of broadband near-infrared (NIR) emission.
Zhigang Gao +8 more
doaj +1 more source