Results 81 to 90 of about 311,065 (292)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Selective doping of Ni2+ in highly transparent glass-ceramics containing nano-spinels ZnGa2O4 and Zn1+x Ga2−2x Ge x O4 for broadband near-infrared fiber amplifiers

Scientific Reports, 2017
Selective doping of Ni2+ in octahedral sites provided by nanocrystals embedded in glass-ceramics (GCs) is crucial to the enhancement of broadband near-infrared (NIR) emission.
Zhigang Gao, Yinyao Liu, Jing Ren, Zaijin Fang, Xiaosong Lu, Elfed Lewis, Gerald Farrell, Jun Yang, Pengfei Wang   +8 more
doaj   +1 more source

High Sensitive Directional Twist Sensor Based on a Mach–Zehnder Interferometer

IEEE Photonics Journal, 2018
A new type of Mach–Zehnder interferometer (MZI) is proposed to measure twist and temperature. The sensor contains a pretwisted taper and a ball. The pretwisted taper is made by pretwisted, and then, thermally tapering along a single-mode fiber, to
Shujie Duan, Weiliang Liu, Cuiting Sun, Hang Jiang, Chong Yao, Kai Zhang, Xingyu Bai, Wen Wang, Cunlian Lu, Tao Geng, Feng Peng, Libo Yuan   +11 more
doaj   +1 more source

Watt-Level Continuous-Wave Mode-Locked Nd:YVO₄ Laser With ReSe₂ Saturable Absorber

IEEE Photonics Journal, 2020
We report a ReSe2 passively mode-locked composite YVO4/Nd:YVO4 laser at 1.06 μm, which can stably generate pure continuous-wave mode-locking (CWML) operation at watt-level output. ReSe2, as a new type of 2-D transition metal dichalcogenides
Yuchen Xue, Li Li, Bin Zhang, Ruoxing Wang, Jinhui Cui, Fengjun Tian, Jianzhong Zhang   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Integrated optics technology study [PDF]

The status and near term potential of materials and processes available for the fabrication of single mode integrated electro-optical components are discussed.
Chen, B., Findakly, T., Innarella, R.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Efficient fluorescence collection from trapped ions with an integrated spherical mirror

, 2010
Efficient collection of fluorescence from trapped ions is crucial for quantum optics and quantum computing applications, specifically, for qubit state detection and in generating single photons for ion-photon and remote ion entanglement.
B. B. Blinov, G. Shu, L.-M. Duan, M. Born, M. R. Dietrich, N. Kurz   +5 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source