Results 81 to 90 of about 49,209 (264)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Ultra-Compact Mach–Zehnder Refractometer Based on Rice-Shaped Air Cavity Beam Expansion
PhotonicsThis paper reports and demonstrates, for the first time, a Mach–Zehnder interferometer (MZI) sensor for refractive index (RI) detection based on a rice-shaped air cavity (RAC).
Zonghao Mu +4 more
doaj +1 more source
Characterisation of fabrication inhomogeneities in Ti:LiNbO3 waveguides
New Journal of Physics, 2019 Nonlinear processes in integrated, guiding systems are fundamental for both classical and quantum experiments. Integrated components allow for compact, modular and stable light-processing systems and as such their use in real-world systems continues to ...
Matteo Santandrea +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Integrated Optical Motion Detection
, 1986 Two systems for detecting the motion of a scene are described. For both, an image is projected directly onto an integrated circuit that contains photosensors and computing circuitry to extract the motion. The first system, which has been reported earlier, correlates the analog image with a digitized version of the image stored from the previous cycle ...
openaire +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Review of Optical Fiber Optofluidic Chemical Sensors and Biosensors
Photonic SensorsOptical fiber sensors have gained significant attention in recent years owing to their remarkable advantages of remote operation and rapid response. The integration of optical fiber sensing with the microfluidics technology has paved the way for the ...
Shuai GAO +8 more
doaj +1 more source