Results 221 to 230 of about 1,439,057 (267)

Respiratory virus surveillance in the post-pandemic era: challenges and opportunities for dashboard-based public health action. [PDF]

BMC Proc
Halley A, Schneeberger C, Stelma FF, Diallo AB, Jollivet O, Boudewijns B, Billard MN, Frome J, Casalegno JS, Lauer KB, Mahé C, Dueger E, Del Riccio M, Descamp A, Maisa A, Hirve S, Caini S, Nunes MC.   +17 more
europepmc   +1 more source

Integration Report V1

A public deliverable on the threestep integration process of ARESIBO componentlevel systemlevel integration with national ...
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The value of C-TIRADS combined with multidimensional indicators in the diagnosis of papillary thyroid carcinoma. [PDF]

Gland Surg
Ya X, Wu H, Wu Y, Li Q, Huang Y.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Components of Service Delivery Models of Care for the Detection, Care and Management of Visual Impairment for Children with Cerebral Visual Impairment: A Scoping Review Protocol. [PDF]

Br Ir Orthopt J
Hepworth LR, Curtis F, Maden M, Williams C, Ravenscroft J, Robinson S, Helliwell B, Croft C, Hill A, Hill R, Tudur Smith C, Rowe FJ.   +11 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Advancing epidemic intelligence: evaluating Senegal's mpox surveillance system and readiness for AI-driven predictive modelling. [PDF]

Front Public Health
Faye SLB, Diongue FB, Ndao A, Diop B, Sow GHC, Dia N, Diakhate F, Gadiaga T, Dieye PS, Gueye OKD, Sall Y, Seck I, Gueye YB, Massaly A, Seydi M, Sy I.   +15 more
europepmc   +1 more source

Preliminary integration Report

Preliminary integration ...
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source