Results 121 to 130 of about 298,694 (309)

Development of a Smart Residential Fire Protection System

Advances in Mechanical Engineering, 2013
Embedded system is applied for the development of smart residential fire detection and extinguishing system. Wireless communication capability is integrated into various fire sensors and alarm devices.
Juhwan Oh, Zhongwei Jiang, Henry Panganiban   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Mobile emergency (surgical) hospital: Development and application in medical relief of “4.20” Lushan earthquake in Sichuan Province, China

Chinese Journal of Traumatology, 2015
In the 21st century, natural disasters and emergencies occur frequently worldwide, which leads to the loss of hundreds of thousands of lives as well as the direct and indirect economic losses.
Cheng Bin, Shi Ruofei, Du Dingyuan, Hu Ping, Feng Jun, Huang Guangbin, Cai Anning, Yin Wei, Yang Ronggang   +8 more
doaj  

WaveGuard: A flood monitoring and rescue system

SoftwareX
Floods hit millions of people every year around the world. In Bangladesh, flooding is a common phenomenon that is often caused by heavy rainfall, monsoon river flooding, and tropical cyclones.
Aritra Naha Likhan, Anirban Roy, Md. Shahidul Salim, Sk Imran Hossain   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An intelligent self‐powered life jacket system integrating multiple triboelectric fiber sensors for drowning rescue

InfoMat
The inherent unpredictability of the maritime environment leads to low rates of survival during accidents. Life jackets serve as a crucial safety measure in underwater environments.
Yiping Zhang, Chengyu Li, Chuanhui Wei, Renwei Cheng, Tianmei Lv, Junpeng Wang, Cong Zhao, Zhaoyang Wang, Fangming Li, Xiao Peng, Minyi Xu, Kai Dong   +11 more
doaj   +1 more source

Simulation-based model course to demonstrate seafarers' competence for deck officers' discipline [PDF]

, 2014
Postprint (published ...
Barahona Fuentes, Claudia, Boran-Keshishyan, A., Castells Sanabra, Marcel·la, Cross, Stephen, Hofman, Wibbo, Kondratiev, A., Moncunill Marimon, Jorge, Muyskens, Cees, Ordás Jiménez, Santiago, Popov, A., Skorokhodov, S.   +10 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source