Results 111 to 120 of about 6,158,970 (292)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Reconstruction of Recreational Catch and Multi-Fisheries Stock Assessment of Hairtail (Trichiurus lepturus) in Korean Waters Under a Data-Limited Situation

Fishes
Accurate catch data are essential for effective fisheries management. This study reconstructs the historical recreational catch of hairtail (Trichiurus lepturus) in Korean waters by incorporating unreported catches to improve stock assessment accuracy ...
Sang Chul Yoon, Moo-Jin Kim, Heejoong Kang, Min-Je Choi   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Municipal sewage sludge management in a changing world: Trends and safe resource recovery

South Sustainability
In this review, we examine municipal sewage sludge management and resource recovery in relation to United Nations Sustainable Development Goal 6 (SDG 6: Clean Water and Sanitation), circular economy goals and public health protection.
Isabel Milagros Gavilan-Figari, Angelica Naka   +1 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Integrated Resource and Environmental Management : The Human Dimension

, 2004
Integrated Resource and Environmental Management (IREM) can be defined as both a management process and a philosophy, that takes into account the many values associated with natural resources within a particular area.\ud \ud This book presents an ...
Ewert, Alan W., Bissix, Glynn C., Baker, Douglas C.   +2 more
core  

Scaling Methods in Regional Integrated Assessments: From Points Upward and from Global Models Downwards [PDF]

, 2005
Scaling methods in regional integrated assessments are often adopted as givens, when in fact there are a range of methods that each have their strengths and weaknesses.
Harrison, P.A., Moss, S., Porter, J., Butterfield, R.E., Iglesias, A., Orr, J.L., Delecolle, R., Bindi, M., Carter, T.R., Downing, T.E., New, M., Olesen, J.E., Harnos, Z.S., Brooks, R.J., Semenov, M.A., Wolf, J.   +15 more
core  

Climate change impacts for ecosystems management in Africa [PDF]

, 2015
The paper is a synthesis of research undertaken by recipients of the African Climate Change Fellowship Program (ACCFP) fellowship awards. The papers focus on: Lake Chad, a transboundary water resource; the Cameroon coastline and socio-economic impacts of
Institute of Resource Assessment
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The question of scale in integrated natural resource management

, 2002
Metadata only recordIntegrated Natural Resource Management is a term used to describe practices that seek to conserve the natural resource base while simultaneously improving agricultural productivity.
Mandondo, A., Moriarty, P., Lovell, C.
core