Results 101 to 110 of about 6,158,970 (292)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Evaluating Modular House Construction Projects: A Delphi Method Enhanced by Conversational AI

Buildings
This study focuses on evaluating modular house construction projects, which is a critical segment within sustainable building practices. Despite the significant advantages of modular construction, such as enhanced resource efficiency and reduced ...
Augustinas Maceika, Andrej Bugajev, Olga R. Šostak   +2 more
doaj   +1 more source

Integral Assessment of the Organizational Human Resources Potential

Business Inform
The aim of the article is to substantiate a methodology for the integral assessment of human resource potential based on modern HR metrics, which reflect both the individual potential of employees and the efficiency of managerial measures in managing them.
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

An Integrated Assessment approach to linking biophysical modelling and economic valuation tools [PDF]

Natural resource management (NRM) typically involves complex decisions that affect a variety of stakeholder values. Efficient NRM, which achieves the greatest net environmental, social and financial benefits, needs to integrate the assessment of ...
Jakeman, Tony, Bennett, Jeffrey W., Kragt, Marit Ellen   +2 more
core  

Draft allocation report pearl oyster (Pinctada maxima) resource / by the Integrated Fisheries Allocation Advisory Committee

, 2016
Integrated Fisheries Management (IFM) is an initiative aimed at addressing the issue of how fish resources in Western Australia should be shared between competing users within the broad context of “Ecologically Sustainable Development”, or ESD, so that ...
Integrated Fisheries Allocation Advisory Committee
core   +2 more sources

Geographical distribution, research trends, and emerging resources of Idesia polycarpa Maxim. in China: a bibliometric analysis

Discover Plants
To systematically understand the research landscape, geographical distribution, and resource variability of Idesia polycarpa Maxim., we integrated bibliometric analysis with empirical phenotype assessments. We analysed 82 articles from the Web of Science
Zhoujian He, Jie Huan, Guangwen Song, Xiaomei Luo, Yunke Liu, Huaxue Wu, Liqiong Jiang, Yuting Lei, Tao Li   +8 more
doaj   +1 more source

Land Use Simulation and Carbon Storage Driving Mechanisms in Resource-Based Regions Under SSP-RCP Scenarios: An Integrated PLUS-InVEST and GWR-SEM Modeling Approach

Land
Amid China’s dual-carbon goals and widening regional disparities, land-use/cover change (LUCC)-induced volatility in carbon storage (CS) has emerged as a binding constraint on emission reduction and the low-carbon transition in resource-based regions ...
Tonghui Yu, Mengting Yang, Xinyu Li, Xuan Zhu, Mengru Wang, Jiqiang Niu   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Measuring cotton’s environmental burden: a dual LCA–emergy framework for conventional and organic systems

Frontiers in Agronomy
Cotton production, a cornerstone of the global textile industry, faces significant environmental challenges due to intensive agrochemical use, water consumption, and soil degradation.
Maggie Dickerson, Sudipta Chowdhury, Md. Abdul Quddus, Ammar Alzarrad   +3 more
doaj   +1 more source